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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >On WD40 proteins propelling our knowledge of transcriptional control?
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On WD40 proteins propelling our knowledge of transcriptional control?

机译：在WD40蛋白上推动我们的转录控制知识？

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A direct effect of post-translational modifications (PTMs) on nucleosomes is the formation of a dynamic platform able to assemble the transcriptional machinery and to recruit chromatin modifiers. The histone code hypothesis suggests that histone PTMs can act as binding sites for chromatin readers and effector proteins, such as the bromodomains, that selectively interact with acetylated lysines, or the "Royal family" and the PHD finger domains, which are able to recognize methylated arginines and lysines. In this review we will discuss recent data describing the function of WD40 proteins as a new class of histone readers, with particular emphasis on the ones able to recognize methylated arginine and lysine residues. We will discuss how WDR5, a classical sevenbladed WD40 propeller, is able to bind with similar affinities both the catalytic subunit of the Trithorax-like complexes, and the histone H3 tail either unmodified or symmetrically dimethylated on arginine 2 (H3R2me2s). Furthermore, we will speculate on how these mutually exclusive interactions of WDR5 may play a role in mediating different degrees of H3K4 methylations at both promoters and distal regulatory sites. Finally, we will summarize recent literature elucidating how other WD40 proteins such as NURF55, EED and LRWD1 recognize methylated histone tails, highlighting similarities and differences among them.
机译：翻译后修饰（PTM）对核小体的直接影响是形成动态平台，该平台能够组装转录机制并募集染色质修饰剂。组蛋白密码假说表明，组蛋白PTM可以充当染色质读取器和效应蛋白（例如与赖氨酸选择性结合的溴结构域或“皇家家族”和PHD手指结构域的结合位点）的结合位点，后者能够识别甲基化精氨酸和赖氨酸。在这篇综述中，我们将讨论描述WD40蛋白作为一类新的组蛋白阅读器的功能的最新数据，特别着重于能够识别甲基化精氨酸和赖氨酸残基的数据。我们将讨论WDR5（经典的七叶WD40螺旋桨）如何能够以相似的亲和力结合Trithorax样复合物的催化亚基以及在精氨酸2（H3R2me2s）上未经修饰或对称二甲基化的组蛋白H3尾巴。此外，我们将推测WDR5的这些相互排斥的相互作用如何在启动子和远端调控位点介导不同程度的H3K4甲基化中发挥作用。最后，我们将总结最近的文献，阐明其他WD40蛋白（例如NURF55，EED和LRWD1）如何识别甲基化的组蛋白尾巴，突出说明它们之间的相似性和差异性。

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