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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Response to: 'response to different measures of 'genome-wide' DNA methylation exhibit unique properties in placental and somatic tissues'
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Response to: 'response to different measures of 'genome-wide' DNA methylation exhibit unique properties in placental and somatic tissues'

机译：回应：“对“全基因组” DNA甲基化的不同测量方法的响应在胎盘和体细胞组织中表现出独特的特性”

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摘要

We are responding to a Letter to the Editor addressing the Method section of our paper "Different measures of 'genome-wide' DNA methylation exhibit unique properties in placental and somatic tissues" (Price ME, Cotton AM, Penaherrera MS, McFadden DE, Kobor MS, Robinson WP. Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues. Epigenetics 2012; 7:652-63; PMID: 22531475; http://dx.doi.org/10.4l6l/epi.20221). The letter raised concerns that the protocol for Epigentek's MethylFlash? kit was followed incorrectly based on the wording of an online publication of our article. We admittedly made an error in the language used to describe the MethylFlash? protocol in our initial submission and thus this was corrected as soon as it was brought to our attention. However, the error was only in language and not procedure. We are confident that the protocol was followed as stated in the insert provided with the MethylFlash? Methylated DNA Quantification kit (Colorimetric).
机译：我们正在回复致编辑的一封信，该信是针对我们论文的“方法”部分的“全基因组DNA甲基化的不同指标在胎盘和体细胞组织中表现出独特的特性”（Price ME，Cotton AM，Penaherrera MS，McFadden DE，Kobor MS，Robinson WP。“全基因组” DNA甲基化的不同测量方法在胎盘和体细胞组织中表现出独特的特性。Epigenetics 2012; 7：652-63; PMID：22531475; http://dx.doi.org/10.4l6l/ epi.20221）。这封信引起了人们对Epigentek的MethylFlash协议的关注？根据我们在线文章的措辞，错误地使用了该工具包。我们承认用描述MethylFlash的语言犯了一个错误。协议在我们的初次提交中得到了解决，因此一经引起我们的注意，便已得到纠正。但是，该错误仅在语言上，而不是过程上。我们有信心按照MethylFlash？随附的插入内容中所述的方法进行操作。甲基化DNA定量试剂盒（比色）。

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