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首页> 外文期刊>Environmental Science and Pollution Research >Chiral profiling of azole antifungals in municipal wastewater and recipient rivers of the Pearl River Delta, China
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Chiral profiling of azole antifungals in municipal wastewater and recipient rivers of the Pearl River Delta, China

机译：珠江三角洲城市污水和受纳河流中唑类抗真菌剂的手性谱

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摘要

Enantiomeric compositions and fractions (EFs) of three chiral imidazole (econazole, ketoconazole, and micona-zole) and one chiral triazole (tebuconazole) antifungals were investigated in wastewater, river water, and bed sediment of the Pearl River Delta, South China. The imidazole pharma-ceuticals in the untreated wastewater were racemic to weakly nonracemic (EFs of 0.450-0.530) and showed weak enantioselectivity during treatment in the sewage treatment plant. The EFs of the dissolved azole antifungals were usually different from those of the sorbed azoles in the suspended paiticulate matter, suggesting different behaviors for the enan-tiomers of the chiral azole antifungals in the dissolved and paiticulate phases of the wastewater. The azole antifungals were widely present in the rivers. The bed sediment was a sink for the imidazole antifungals. The imidazoles were prevalently racemic, whereas tebuconazole was widely nonracemic in the rivers. Seasonal effects were observed on distribution and chirality of the azole antifungals. Concentrations of the azole antifungals in the river water were relatively higher in winter than in spring and summer while the EF of miconazole in the river water was higher in summer. The mechanism ofenantiomeric behavior of the chiral azole antifungals in the environment warrants further research.
机译：在华南珠江三角洲的废水，河水和床底沉积物中，研究了三种手性咪唑（益康唑，酮康唑和micona-zole）和一种手性三唑（戊康唑）抗真菌剂的对映体组成和馏分（EFs）。未经处理的废水中的咪唑药物为消旋至弱非消旋性（EF为0.450-0.530），在污水处理厂的处理过程中对映选择性较弱。悬浮的颗粒状物质中溶解的吡咯类抗真菌剂的EF通常不同于吸附的吡咯类物质，这表明手性吡咯类抗真菌剂的对映异构体在废水的溶解相和颗粒状相中的行为不同。唑类抗真菌药广泛存在于河流中。床沉淀物是咪唑抗真菌剂的汇。咪唑普遍是外消旋的，而戊唑醇在河流中是广泛的非外消旋的。在唑类抗真菌剂的分布和手性上观察到季节性影响。冬季，河水中的吡咯类抗真菌药的浓度要比春季和夏季高，而夏季用水中咪康唑的EF要高。手性唑类抗真菌剂在环境中的对映体行为机理值得进一步研究。

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