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首页> 外文期刊>Biochimica et biophysica acta. Gene structure and expression >Molecular characterization of type E Clostridium botulinum and comparison to other types of Clostridium botulinum
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Molecular characterization of type E Clostridium botulinum and comparison to other types of Clostridium botulinum

机译：E型肉毒梭菌的分子表征及与其他类型肉毒梭菌的比较

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摘要

Determination of nucleotide sequence upstream to the neurotoxin binding protein (NBP) gene of type E Clostridium botulinum has revealed an open reading frame whose stop codon is only 18bp apart from the start codon of the NBP gene. Amino acid sequence derived from the corresponding nucleotide sequence suggested the existence of the open reading frame as a 47.8 kDa protein (P-48). Protein data bank search revealed that the 47.8 kDa protein has 80% sequence identity to P-47 of type F C. botulinum. The gene organization of type E. Clostridium botulinum was predicted and compared to other types of C. botulinum. In type E C. botulinum, genes for the P-48, the neurotoxin binding protein and the neurotoxin form an operon which was similar to that of type F C. botulinum. However, type E C. botulinum has a P-18 gene instead of P-21 gene observed in type F C. botulinum, both located upstream to their respective P-48/P-47 gene.
机译：对E型肉毒梭菌神经毒素结合蛋白（NBP）基因上游核苷酸序列的确定揭示了一个开放阅读框，其终止密码子与NBP基因的起始密码子仅相距18bp。源自相应核苷酸序列的氨基酸序列表明，开放阅读框的存在为47.8 kDa蛋白（P-48）。蛋白质数据库搜索显示，该47.8 kDa蛋白质与F.肉毒杆菌P-47具有80％的序列同一性。预测了类型的肉毒梭菌的基因组织，并将其与其他类型的肉毒梭菌进行了比较。在肉毒梭状芽孢杆菌中，P-48，神经毒素结合蛋白和神经毒素的基因形成一个操纵子，其类似于肉毒梭状芽孢杆菌的操纵子。但是，大肠杆菌型肉毒杆菌具有P-18基因，而不是在肉毒杆菌型肉毒杆菌中观察到的P-21基因，它们都位于各自的P-48 / P-47基因的上游。

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