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首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >First seizure definitions and worldwide incidence and mortality.
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First seizure definitions and worldwide incidence and mortality.

机译:首次癫痫发作的定义以及全世界的发病率和死亡率。

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摘要

While all patients with epilepsy experience seizures, not all individuals with seizures have epilepsy. Seizures may be acute symptomatic or unprovoked. Acute symptomatic seizures are seizures occurring at the time of a systemic insult or in close temporal association with a documented brain insult. Unprovoked seizures are seizures occurring in the absence of precipitating factors and may be caused by a static injury (remote symptomatic seizures) or a progressing injury (progressive symptomatic seizures). Unprovoked seizures may be single or recurrent (epilepsy). The incidence of acute symptomatic seizures is 29-39 per 100,000 per year. These predominate in men, in the youngest age class, and in the elderly. Traumatic brain injury, cerebrovascular disease, drug withdrawal, infarction, and metabolic insults are the commonest causes. The incidence of single unprovoked seizures is 23-61 per 100,000 person-years. As with epilepsy, single unprovoked seizures predominate in men and in patients less than 12 months and older than 65 years. Studies on the mortality of acute symptomatic seizures are lacking. A standardized mortality ratio (SMR) of 2.3 has been reported in patients experiencing a single unprovoked seizure. The SMR in patients with a newly diagnosed unprovoked seizure ranges from 2.5 to 4.1 according to the study population and design. The SMR is highest in the youngest patients and in those with symptomatic seizures.
机译:尽管所有癫痫病患者都患有癫痫病,但并非所有癫痫病患者都患有癫痫病。癫痫发作可能是急性症状或无故发作。急性症状性癫痫发作是在全身性损伤或与已记录的脑部损伤在时间上紧密相关时发生的癫痫发作。无缘无故的癫痫发作是在没有诱发因素的情况下发生的癫痫发作,可能是由静态损伤(远程症状性癫痫发作)或进行性损伤(渐进性症状性癫痫发作)引起的。无缘无故的癫痫发作可能是单发或反复发作​​(癫痫)。急性症状性癫痫发作的发生率为每年每100,000例29-39例。这些在男性,最年轻的年龄段以及老年人中占主导地位。颅脑外伤,脑血管疾病,停药,梗塞和代谢损伤是最常见的原因。单发性无性癫痫发作的发生率为每100,000人年23-61。与癫痫病一样,男性和少于12个月且超过65岁的患者中,单发性无故癫痫发作居多。缺乏对急性症状性癫痫发作死亡率的研究。据报道,发生一次无故癫痫发作的患者的标准死亡率(SMR)为2.3。根据研究人群和设计,新诊断为无因发作的癫痫患者的SMR为2.5至4.1。 SMR在最年轻的患者和有症状性癫痫的患者中最高。

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