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首页> 外文期刊>Epilepsy & behavior: E&B >Distinguishing between patients with pure psychogenic nonepileptic seizures and those with comorbid epilepsy by means of clinical data
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Distinguishing between patients with pure psychogenic nonepileptic seizures and those with comorbid epilepsy by means of clinical data

机译：通过临床资料区分纯精神病性非癫痫性癫痫患者和合并症癫痫患者

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Patients with psychogenic nonepileptic seizures (PNESs) often have additional epileptic seizures (ESs). Distinguishing between those with ESs and those without ESs is difficult but mandatory. We hypothesize that these two patient groups differ in clinical data, which might be useful for establishing diagnosis. All patients with PNESs (n = 114) from the Bethel Epilepsy Centre treated between 1/11/2010 and 1/11/2011 were included. Thirty-six percent had additional epilepsy. In contrast, 84 of the 114 patients with PNESs took antiepileptic drugs (AEDs) (AED treatment: patients with PNESs = 44/73, patients with PNESs + ESs = 40/41), most of them (65.5%) as polytherapy. Significant differences between both groups were as follows: patients with PNESs were older at disease onset, had a shorter duration from onset to inpatient visit, were less frequently on AEDs, were less frequently on antiepileptic polytherapy, and had a normal EEG compared with patients with PNESs + ESs. Multivariate stepwise logistic regression revealed age at seizure onset, number of AEDs, and difference between number of AEDs and psychiatric drugs as significant predictors of patients with ESs in PNESs (Nagelkerke's r(2) = 0.59). Therefore, clinical data proved to be useful in the diagnostic process. (C) 2014 Elsevier Inc. All rights reserved.
机译：患有精神病性非癫痫性癫痫发作（PNESs）的患者通常还有其他癫痫性癫痫发作（ESs）。区分具有ES的人和没有ES的人是困难的，但必须这样做。我们假设这两个患者组的临床数据不同，这可能对确定诊断有用。纳入了所有在2010年11月1日至2011年11月11日期间接受了Bethel癫痫中心治疗的PNESs（n = 114）的患者。 36％的患者患有其他癫痫病。相比之下，在114例PNESs患者中，有84例服用了抗癫痫药物（AED）（AED治疗：PNESs患者= 44/73，PNESs + ESs患者= 40/41），其中大多数（65.5％）为多药疗法。两组之间的显着差异如下：与PNESs患者相比，PNESs患者在疾病发作时年龄较大，从发作到住院就诊的时间较短，AED的频率较低，抗癫痫综合疗法的频率较低，并且EEG正常PNES + ES。多元逐步logistic回归显示癫痫发作的年龄，AED的数量以及AED和精神药物的数量之间的差异是PNESs ES患者的重要预测指标（Nagelkerke's r（2）= 0.59）。因此，临床数据被证明在诊断过程中是有用的。 （C）2014 Elsevier Inc.保留所有权利。

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