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首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >Distribution and conspicuity of intracranial abnormalities on MR imaging in adults with tuberous sclerosis complex: A comparison of sequences including ultrafast T2-weighted images.
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Distribution and conspicuity of intracranial abnormalities on MR imaging in adults with tuberous sclerosis complex: A comparison of sequences including ultrafast T2-weighted images.

机译：成人结节性硬化症患者磁共振成像的颅内异常分布和显着性：序列比较，包括超快T2加权图像。

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PURPOSE: Tuberous sclerosis complex produces a wide range of intracranial pathologies, the most common being cortical tubers and subependymal nodules. This study evaluates which magnetic resonance (MR) sequences show the pathology best and to see if "ultrafast" sequences can show the pathology robustly. METHODS: MR imaging was performed on 29 adults with tuberous sclerosis complex. Anatomically matched 5-mm-thick sections were taken in the axial plane using four different sequences, including single shot fast spin echo as the ultrafast method. The ability of those sequences to show cortical tubers and subependymal nodules was assessed by reporting each sequence independently and comparing with the reference standard report based on all of the sequences together. RESULTS: A total of 219 cortical tubers were shown in the 29 people; three did not have cortical tubers. Cortical tubers were best delineated on fluid-attenuated inversion recovery (FLAIR) images (false-negative rate <0.5%) followed by the T(2)-weighted images (false-negative rate 21%). The single-shot fast spin echo and gradient echo T(2)* sequences both failed to show more than 50% of cortical tubers. Subependymal nodules were shown in 24 of 29 people and the gradient echo T(2)* sequence showed that pathology best in all 24 cases. DISCUSSION: Our study shows that single-shot fast spin echo sequences do not sufficiently show the expected intracranial complications of tuberous sclerosis complex and should not be considered as an alternative to standard sequences in this group. Cortical tubers are shown exceptionally well on FLAIR images, whereas subependymal nodules (and calcified tubers) are best shown on gradient echo T(2)* images.
机译：目的：结节性硬化症产生多种颅内病变，最常见的是皮质块茎和室管膜下结节。这项研究评估了哪些磁共振（MR）序列最能显示病理学，并查看“超快”序列是否可以强有力地显示病理学。方法：对29例结节性硬化症成年人进行了MRI检查。在解剖学上匹配的5毫米厚的切片在轴向平面上使用四种不同的顺序进行了拍摄，包括单次快速自旋回波作为超快方法。通过独立报告每个序列并与所有序列一起基于参考标准报告进行比较，评估了这些序列显示皮质块茎和室管膜下结节的能力。结果：29人中共显示219个皮质块茎。三个没有皮质块茎。皮质块茎最好在液体衰减倒置恢复（FLAIR）图像（假阴性率<0.5％）上描绘，然后是T（2）加权图像（假阴性率21％）。单次快速自旋回波和梯度回波T（2）*序列均无法显示超过50％的皮质块茎。在29人中有24人显示了室管膜下结节，并且梯度回波T（2）*序列显示在所有24例患者中，病理表现最佳。讨论：我们的研究表明，单次快速自旋回波序列不足以显示结节性硬化症复合体的预期颅内并发症，因此不应视为该组中标准序列的替代方法。皮质块茎在FLAIR图像上显示得异常好，而室管膜下结节（和钙化的块茎）在梯度回波T（2）*图像上显示得最好。

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