...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Epilepsy research >Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy
【24h】

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy

机译：遗传性和后天性癫痫动物模型中的轴突初始区段结构可塑性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel form of neuronal plasticity, occurring at the axon initial segment (AIS), has recently been described. Lengthening of the AIS and movement away from the soma are consequences of changes in neuronal input and result in alterations in neuronal excitability. We hypothesised that AIS plasticity may play a role in epilepsy, due to chronic changes in neuronal activity. Immunohistochemistry and confocal microscopy were used to analyse AIS length and position in pyramidal neurons in deep layer 5 of the somatosensory cortex from 5 mice with genetic epilepsy and 4 controls, and from 3 rats subjected to amygdala kindling and 3 controls. The effect of a subtle alteration of AIS position was modelled computationally.We identified a difference in the position of the AIS in animals with seizures: in mice the AIS was positioned 0.2. μm further away from the soma, and in rats the AIS was positioned 0.6. μm closer to the soma compared with controls. Computational modelling indicated that a subtle alteration in AIS position could result in a change in action potential firing threshold.The identification of AIS plasticity in animal models of epilepsy is significant in furthering our understanding of the pathophysiological mechanisms involved in this disorder.
机译：最近已经描述了一种新形式的神经元可塑性，其发生在轴突起始节（AIS）。 AIS的延长和远离躯体的运动是神经元输入变化的结果，并导致神经元兴奋性改变。我们假设由于神经元活动的慢性变化，AIS可塑性可能在癫痫中起作用。免疫组织化学和共聚焦显微镜分析了5只具遗传癫痫病的小鼠和4只对照以及3名接受杏仁核点燃和3只对照的体感皮质深层5层锥体神经元的AIS长度和位置。通过计算机模拟AIS位置微妙变化的影响。我们确定了癫痫发作动物的AIS位置存在差异：在小鼠中，AIS的位置为0.2。距离躯体更远，距离μm，并且大鼠的AIS位置为0.6。与对照组相比，更靠近躯体的μm。计算模型表明，AIS位置的细微变化可能会导致动作电位触发阈值的变化。在癫痫动物模型中识别AIS可塑性对于进一步了解这种疾病的病理生理机制具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号