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Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers

机译:沥青工人职业队列中的咽部和扁桃体癌

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Background: We investigated a possible association between pharyngeal/tonsillar carcinoma and mixed carcinogen exposures in an asphalt roll company in Italy that used asbestos until 1979, when a new factory was built using a different production process. Methods: We evaluated all workers involved in the entire production history of the company, divided into two subcohorts based on exposure status (workers in the original factory, 1964-1979, and those who worked only in the new factory, 1980-1997). We ascertained the vital status of the study population in February 2001. Results: Among the subset of workers in the earlier subcohort, there were five deaths from pharyngeal/tonsillar carcinoma for a standardized mortality ratio of 21 (95% confidence interval = 8.8-51). No cases were recorded among workers hired after 1979. Conclusion: The increased standardized mortality ratio for this relatively rare cancer among workers exposed before 1979 may have been due to carcinogenic exposures at the plant.
机译:背景:我们调查了意大利的一家使用石棉的沥青卷公司(直到1979年,当时使用不同生产工艺建造的新工厂)中咽/扁桃体癌与混合致癌物暴露之间的可能联系。方法:我们评估了公司整个生产历史中涉及的所有工人,根据接触状况分为两个小组(原始工厂的工人为1964-1979年,仅在新工厂的工人为1980-1997年)。我们确定了2001年2月研究人群的生命状态。结果:在早期亚人群中,有5例咽/扁桃体癌死亡,标准死亡率为21(95%置信区间= 8.8-51)。 )。 1979年以后雇用的工人中没有记录到任何病例。结论:1979年之前接触这种相对罕见的癌症的标准死亡率的增加,可能是由于该工厂暴露于致癌物所致。

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