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首页> 外文期刊>Epidemiology >Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry.
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Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry.

机译：有关氯乙烯行业的欧洲工人死亡率和癌症发病率的最新跟踪报道。

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Although vinyl chloride is an established cause of liver angiosarcoma, the evidence is inconclusive on whether it also causes other neoplastic and nonneoplastic chronic liver diseases as well as neoplasms in other organs. Furthermore, the shape of the dose-response relation for angiosarcoma is uncertain. We have extended for approximately 8 years the mortality and cancer incidence follow-up of 12,700 male workers in the vinyl chloride industry in four European countries. All-cause mortality was lower than expected, whereas cancer mortality was close to expected. A total of 53 deaths from primary liver cancer (standardized mortality ratio 2.40, 95% confidence interval = 1.80-3.14) and 18 incident cases of liver cancer were identified, including 37 angiosarcomas, 10 hepatocellular carcinomas, and 24 liver cancers of other and unknown histology. In Poisson regression analyses we observed a marked exposure response for all liver cancers, angiosarcoma, and hepatocellular carcinoma. The exposure-response trend estimated for liver cancer in analyses restricted to cohort members with cumulative exposures of <1,500 parts per million-years was close to that estimated for the full cohort (relative risk of 2.0 per logarithmic unit of cumulative dose). No strong relation was observed between cumulative vinyl chloride exposure and other cancers. Although cirrhosis mortality was decreased overall, there was a trend with cumulative exposure.
机译：尽管氯乙烯是肝脏血管肉瘤的既定原因，但关于氯乙烯是否还会引起其他肿瘤性和非肿瘤性慢性肝病以及其他器官的肿瘤，尚无定论。此外，血管肉瘤的剂量反应关系的形状是不确定的。我们已经将大约四个欧洲国家的氯乙烯行业的12,700名男性工人的死亡率和癌症发病率随访时间延长了大约8年。全因死亡率低于预期，而癌症死亡率接近预期。总共鉴定出53例原发性肝癌死亡（标准死亡率为2.40，95％置信区间= 1.80-3.14），其中18例发生肝癌，其中包括37例血管肉瘤，10例肝细胞癌和24例其他未知的肝癌组织学。在泊松回归分析中，我们观察到了所有肝癌，血管肉瘤和肝细胞癌的显着暴露反应。在仅限于队列成员的分析中，肝癌的暴露-响应趋势估计为<百万分之1500累计暴露量，接近整个队列的估计值（相对危险度为每对数单位累积剂量2.0。在累积的氯乙烯暴露与其他癌症之间未观察到强烈关系。尽管肝硬化的死亡率总体上降低了，但存在累积暴露的趋势。

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