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E-cadherin expression in Barrett's esophagus and esophageal carcinoma

机译：E-钙黏着蛋白在巴雷特食管和食道癌中的表达

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Introduction In multicellular organisms the development of adhesion bonds either among cells or among cells and components of the extracellular matrix is a crucial process. These interactions are mediated by molecules, named adhesion molecules. Their molecular and genetic structure, their biochemical role and their functional characteristics are nowadays clearly determined. At present, adhesion molecules embrace five categories: cadherins, integrins, immunoglobulin gene superfamily members, selectins and CD44. Cadherins are the most interesting group among all adhesion molecules, given the fact that at their presence all adhesion interactions may be continued, despite the potential absence of all of the remainder of the adhesion molecule groups. Cadherins apart from playing a crucial role in tissue architecture formation and maintenance in adult animals and humans, they play an equal importance role in tissue architecture alteration/distortion. This latter role is unambiguous nowadays and the most extensively studied paradigm occurs in carcinogenesis. E-cadherin down-regulation is a general phenomenon observed in many malignant lesions in humans including head and neck, esophageal, gastric, colorectal, pancreatic, primary liver, prostate, and bladder cancer, as well as in pre-malignant lesions including Barrett's esophagus, and cervical intraepithelial neoplasia. Materials and methods Review article. Conclusion In this review we try to elucidate the expression of E-cadherin and related molecules in Barrett's esophagus as well as in malignant lesions of the esophagus like adenocarcinoma and squamous cell carcinoma.
机译：引言在多细胞生物中，细胞之间或细胞与细胞外基质成分之间的粘附键的形成是至关重要的过程。这些相互作用由称为粘附分子的分子介导。如今已经清楚地确定了它们的分子和遗传结构，其生化作用及其功能特性。目前，粘附分子包括五类：钙粘着蛋白，整联蛋白，免疫球蛋白基因超家族成员，选择蛋白和CD44。钙黏着蛋白是所有黏附分子中最有趣的基团，因为事实上，尽管可能不存在所有其余的黏附分子组，但所有黏附相互作用仍会继续。钙黏着蛋白除了在成年动物和人类的组织结构形成和维持中起关键作用外，在组织结构改变/畸变中也起着同等重要的作用。如今，后者的作用是明确的，最广泛研究的范式发生在致癌作用中。 E-钙粘蛋白下调是在人类的许多恶性病变中观察到的普遍现象，包括头颈部，食道癌，胃癌，结肠直肠癌，胰腺癌，原发性肝癌，前列腺癌和膀胱癌，以及恶性前病变（包括巴雷特食管）和宫颈上皮内瘤变。材料和方法评论文章。结论在这篇综述中，我们试图阐明E-钙粘蛋白及其相关分子在巴雷特食管以及食管恶性病变如腺癌和鳞状细胞癌中的表达。

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