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Esophageal endocrine cell carcinoma: a report of eight cases and a review of the literature

机译：食管内分泌细胞癌：八例报告并文献复习

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摘要

Esophageal endocrine cell carcinoma is a rare histopathological type thought to be highly malignant and to have a poor prognosis, but its clinical behavior has not been fully analyzed. We retrospectively reviewed our cases among 386 patients with esophageal cancer in our institution. Eight patients (2.1 %) were pathologically diagnosed with endocrine cell carcinoma. Median patient age was 63 years, and the male-to-female ratio was 7:1. Cancer stage according to the Japanese Classification of Esophageal Cancer (JCEC) 10th edition, was stage II in one case, III in three, IVa in one, and IVb in three. Chromogranin-A staining was positive in six cases, synaptophysin in six, cluster of differentiation (CD)56 in seven, and neuron-specific enolase (NSE) in seven. Treatment included surgery in two cases, chemoradiotherapy in four, best-supportive case in one, and rejection in one. Prognoses were 13 months after surgery for stage II, 6-28 months after chemoradiotherapy for stage III, and 0-10 months for stage IV.
机译：食管内分泌细胞癌是一种罕见的组织病理学类型，被认为是高度恶性且预后较差，但其临床行为尚未得到充分分析。我们回顾性回顾了我院386例食管癌患者中的病例。经病理学诊断为内分泌细胞癌的有8例（2.1％）。患者年龄中位数为63岁，男女比例为7：1。根据日本《食管癌分类》（JCEC）第10版，癌症分期为II例，III例，三例，IVa例，IVb例。嗜铬粒蛋白-A染色阳性6例，突触素阳性6例，分化簇（CD）56阳性7例，神经元特异性烯醇化酶（NSE）阳性7例。治疗包括手术2例，放化疗4例，最佳支持1例，排斥反应1例。 II期手术后13个月，III期放化疗后6-28个月，IV期0-10个月。

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