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Inflammatory myofibroblastic tumor in the esophagus after treatment for superficial esophageal cancer

机译:浅表食管癌治疗后食管炎性肌纤维母细胞瘤

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摘要

A 76-year-old man was referred to our hospital for treatment of a submucosal tumor in the esophagus. The patient had a history of superficial esophageal cancer treated by endoscopic resection and radiation. Positron emission tomography showed intense localized uptake of fluorodeoxyglucose on the esophageal mass. Transthoracic esophagectomy and reconstruction with a gastric tube were performed. Histopathological examination revealed that the tumor consisted of a proliferation of atypical spindle cells with infiltration of many inflammatory cells. The spindle cells were positive for vimentin, alpha smooth muscle actin, and anaplastic lymphoma kinase immunostaining. The Ki-67 labeling index was 10-20 %. The tumor was finally diagnosed as inflammatory myofibroblastic tumor. Late phase inflammation caused by radiation potentially had an effect on the occurrence of the tumor in this case. For tumors of the irradiated esophagus, especially, careful pretreatment examination and treatment strategies with consideration of the radiation damage are important-to obtaining a favorable outcome.
机译:一名76岁的男子被转诊到我院治疗食道粘膜下肿瘤。该患者有经内镜切除和放射治疗的浅表食管癌病史。正电子发射断层显像显示氟脱氧葡萄糖在食管肿块上的强烈局部摄取。经胸食管切除术和胃管重建。组织病理学检查显示该肿瘤由非典型梭形细胞的增殖和许多炎性细胞的浸润组成。梭形细胞对波形蛋白,α平滑肌肌动蛋白和间变性淋巴瘤激酶免疫染色呈阳性。 Ki-67标记指数为10-20%。该肿瘤最终被诊断为炎性肌纤维母细胞瘤。在这种情况下,由辐射引起的晚期炎症潜在地影响肿瘤的发生。特别是对于被辐射的食道肿瘤,仔细的预处理检查和考虑放射线损害的治疗策略对于获得良好的结果很重要。

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