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Clinical features and prognostic factors of brain metastasis from esophageal carcinoma

机译：食管癌脑转移的临床特征和预后因素

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Background Brain metastasis from esophageal carcinoma is uncommon. The aims of this study were to assess the frequency of brain metastasis from esophageal carcinoma, describe treatment modalities and their outcomes, and determine predictors of survival. Methods Between 2004 and 2012, 680 patients with esophageal carcinoma were registered at Keio University Hospital, Tokyo, Japan. Of these patients, 16 (2.3 %) were diagnosed with brain metastasis. We reviewed their medical records and performed statistical analyses. Results The median survival after diagnosis of brain metastasis was 5.0 months (95 % CI 1.2-8.7 months). The only statistically significant baseline characteristic that predicted worse survival from brain metastasis was the onset form of brain metastasis (p = 0.01). At the onset of brain metastasis, the median survival from brain metastasis was 13.0 months (95 % CI 0.0-31.0 months) in patients without extracranial metastasis and 2.0 months (95 % CI 0.0-4.3 months) in patients with extracranial metastasis (p = 0.01). Conclusions Approximately 2 % patients with esophageal carcinoma were diagnosed with brain metastasis. The prognosis of brain metastasis is extremely poor, but long-term survival may be expected with intensive treatment for brain metastasis when the first metastatic site is the brain.
机译：背景食管癌的脑转移并不常见。这项研究的目的是评估食管癌脑转移的频率，描述治疗方式及其结果，并确定生存预测因素。方法2004年至2012年，在日本东京庆应义Hospital大学医院对680例食道癌患者进行了登记。在这些患者中，有16名（2.3％）被诊断为脑转移。我们审查了他们的病历并进行了统计分析。结果诊断为脑转移后的中位生存期为5.0个月（95％CI为1.2-8.7个月）。预测脑转移生存恶化的唯一具有统计学意义的基线特征是脑转移的发作形式（p = 0.01）。在发生脑转移时，无颅外转移的患者的脑转移中位生存期为13.0个月（95％CI 0.0-31.0个月），有颅外转移的患者中位生存期为2.0个月（95％CI 0.0-4.3个月）（p = 0.01）。结论约2％的食管癌患者被诊断为脑转移。脑转移的预后极差，但当第一个转移部位为脑时，对脑转移进行强化治疗可望长期存活。

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