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首页> 外文期刊>Esophagus >Predictive factors for early recurrence in patients with esophageal squamous cell carcinoma after curative esophagectomy
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Predictive factors for early recurrence in patients with esophageal squamous cell carcinoma after curative esophagectomy

机译：食管根治性切除术后食管鳞状细胞癌早期复发的预测因素

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Background Even after curative resection with combined modality treatment by chemotherapy and radiation, esophageal cancer has remained a disease with poor prognosis upon early recurrence. In this study, the clinicopathological predictive factors for early recurrence in patients with curative resected esophageal cancer were retrospectively evaluated. Methods Eighty-one consecutive patients who had recurrence of primary esophageal squamous cell carcinoma after curative resection were analyzed. The patients were classified into two subgroups by time of recurrence (within 180 days of surgery or later): an early group and a late group.Results Twenty-seven (33.3%) and 54 (66.7%) patients were classified into the early and late groups, respectively. Patients in the early group had significantly deeper tumors than those in the late group. The initial recurrence patterns were not significantly different between the two groups, and distant recurrences were found in two-thirds of patients in both groups. The 1-year survival rates of patients in the early and late groups were 11 and 62%, respectively. The survival rate after recurrence of patients in the early group was significantly poorer than that of patients in the late group (p < 0.0001). Multivariate logistic regression analysis revealed that the presence of three or more pathological lymph node metastases was an independent risk factor associated with early recurrence.Conclusions Early distant recurrences of esophageal cancer frequently occurred even after curative surgery. The number of pathological lymph node metastases (three or more) was the independent risk factor for early recurrence in patients with esophageal cancer after curative resection.
机译：背景技术即使在通过化学疗法和放射疗法联合根治性切除术之后，食管癌仍是早期复发后预后较差的疾病。在这项研究中，回顾性分析了治愈性食管癌患者早期复发的临床病理预测因素。方法对81例原发性食管鳞状细胞癌根治性切除术后复发的患者进行分析。按复发时间（手术180天或更晚）将患者分为两个亚组：早期组和晚期组。结果有27例（33.3％）和54例（66.7％）分为早期和晚期。后期组。早期组的患者比晚期组的患者肿瘤深得多。两组之间的初始复发模式无显着差异，两组中三分之二的患者均发现远处复发。早期和晚期组患者的1年生存率分别为11％和62％。早期组患者的复发后生存率明显低于晚期组（p <0.0001）。多因素logistic回归分析显示，存在3个或更多病理性淋巴结转移是与早期复发相关的独立危险因素。结论即使在治愈性手术后，食管癌的早期远距离复发也很常见。病理性淋巴结转移的数量（三个或更多）是食管癌根治性切除术后早期复发的独立危险因素。

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