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首页> 外文期刊>European eating disorders review >Lisdexamfetamine Dimesylate Effects on Binge Eating Behaviour and Obsessive-Compulsive and Impulsive Features in Adults with Binge Eating Disorder
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Lisdexamfetamine Dimesylate Effects on Binge Eating Behaviour and Obsessive-Compulsive and Impulsive Features in Adults with Binge Eating Disorder

机译：Lisdexamfetamine Dimesylate对暴饮暴食成人的暴饮暴食行为及强迫和冲动特征的影响

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In a published 11-week, placebo-controlled trial, 50 and 70mg/d lisdexamfetamine dimesylate (LDX), but not 30mg/d LDX, significantly reduced binge eating days (primary endpoint) in adults with binge eating disorder (BED). This report provides descriptions of LDX effects on secondary endpoints (Binge Eating Scale [BES]; Three-Factor Eating Questionnaire [TFEQ]; Yale-Brown Obsessive Compulsive Scale modified for Binge Eating [Y-BOCS-BE]; and the Barratt Impulsiveness Scale, version 11 [BIS-11]) from that study. Week 11 least squares mean treatment differences favoured all LDX doses over placebo on the BES (p0.03), TFEQ Disinhibition and Hunger subscales (all p<0.05), and Y-BOCS-BE total, obsessive, and compulsive scales (all p0.02) and on BIS-11 total score at 70mg/d LDX (p=0.015) and the TFEQ Cognitive Restraint subscale at 30 and 70mg/d LDX (both p<0.05). These findings indicate that LDX decreased global binge eating severity and obsessive-compulsive and impulsive features of BED in addition to binge eating days. Copyright (c) 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
机译：在一项已公布的为期11周的安慰剂对照试验中，使用50和70mg / d的赖氨苯丙胺二甲磺酸盐（LDX），而不是30mg / d LDX可以显着减少患有暴食症（BED）的成年人的暴食天数（主要终点）。该报告提供了LDX对次要终点的影响的描述（宾果饮食量表[BES];三因素饮食问卷[TFEQ];为暴饮暴食而修改的耶鲁-布朗强迫症量表[Y-BOCS-BE];以及巴拉特冲动量表，该研究的第11版[BIS-11]）。第11周的最小二乘均值意味着在BES（p0.03），TFEQ抑制和饥饿子量表（p <0.05）和Y-BOCS-BE总，强迫和强迫量表（p0）上，所有LDX剂量均优于安慰剂。 .02）和BIS-11的总得分分别为70mg / d LDX（p = 0.015）和TFEQ认知约束子量表，分别为30和70mg / d LDX（p <0.05）。这些发现表明，LDX不仅减少了暴饮暴食天，还降低了全球暴饮暴食的严重程度以及BED的强迫症和冲动特征。版权所有（c）2015 John Wiley＆Sons，Ltd和饮食失调协会。

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