Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster

Aavik Einari; Lumivuori Henri; Leppanen Olli; Wirth Thomas; Hakkinen Sanna-Kaisa; Braesen Jan-Hinrich; Beschorner Ulrich; Zeller Thomas; Braspenning Maarten; van Criekinge Wim; Makinen Kimmo; Yla-Herttuala Seppo

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Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster

机译：全球人类的动脉粥样硬化斑块的DNA甲基化分析揭示了广泛的基因组甲基化不足和印迹位点14q32的重新激活，涉及miRNA簇的诱导。

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Aims Genetics can explain just above 10% of the observed heritability in cardiovascular diseases. Epigenetics is about to provide some further explanations, but the information needed for that is in the accumulation phase. Genome-wide DNA methylation analysis has revealed thousands of genes, which are epigenetically differentially regulated in atherosclerotic plaques. Our results point to an additional level of complexity that needs to be integrated into the aetiology of atherogenesis.We conducted a genome-wide analysis to identify differentially methylated genes in atherosclerotic lesions.

机译：目的遗传学可以解释心血管疾病中所观察到的遗传力的10％以上。表观遗传学将提供一些进一步的解释，但这所需的信息仍在积累阶段。全基因组DNA甲基化分析已揭示了成千上万的基因，这些基因在动脉粥样硬化斑块中在表观遗传上受到差异调节。我们的结果表明需要将复杂程度提高到动脉粥样硬化的病因中。我们进行了全基因组分析，以鉴定动脉粥样硬化病变中差异甲基化的基因。

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《European Heart Journal: The Journal of the European Society of Cardiology》 |2015年第16期|共8页
作者
Aavik Einari; Lumivuori Henri; Leppanen Olli; Wirth Thomas; Hakkinen Sanna-Kaisa; Braesen Jan-Hinrich; Beschorner Ulrich; Zeller Thomas; Braspenning Maarten; van Criekinge Wim; Makinen Kimmo; Yla-Herttuala Seppo;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Atherosclerosis; DNA methylation; Epigenetics; Peripheral vascular disease;

机译：动脉粥样硬化;DNA甲基化;表观遗传学;周围血管疾病;

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外文文献

1. Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster [J] . Aavik Einari, Lumivuori Henri, Leppanen Olli, European Heart Journal: The Journal of the European Society of Cardiology . 2015,第16期

机译：全球人类的动脉粥样硬化斑块的DNA甲基化分析揭示了广泛的基因组甲基化不足和印迹位点14q32的重新激活，涉及miRNA簇的诱导。
2. P1.02-050 Pan-Can Analysis of miRNAs at the Imprinted Chromosome 14q32 Locus Reveals a Unique Pattern of Deregulation in NSCLC [J] . J. Enterina, W. Lam Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2017,第11期

机译：P1.02-050 Pan-CaN可以在印迹染色体14Q32轨迹处分析miRNA，揭示了NSCLC中的独特放松潜水模式
3. SIMULTANEOUS ANALYSIS OF DNA METHYLATION AND MIRNA EXPRESSION IN ATHEROSCLEROTIC PLAQUES OF CAROTID ARTERIES [J] . Zarubin A., Markov A., Sharysh D., Atherosclerosis . 2019,第期

机译：颈动脉动脉动脉动脉粥样硬化斑块中DNA甲基化和miRNA表达的同时分析
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Genomic and epigenomic characterization of global DNA hypomethylation in human epithelial ovarian cancer [D] . Zhang, Wa. 2014

机译：人类上皮性卵巢癌中整体DNA低甲基化的基因组和表观基因组学表征
6. The Upregulation of Genomic Imprinted DLK1-Dio3 miRNAs in Murine Lupus Is Associated with Global DNA Hypomethylation [O] . Rujuan Dai, Ran Lu, S. Ansar Ahmed -1

机译：小鼠狼疮中的基因组印迹DLK1-Dio3 miRNA的上调与全球DNA次甲基化有关。
7. The Upregulation of Genomic Imprinted DLK1-Dio3 miRNAs in Murine Lupus Is Associated with Global DNA Hypomethylation. [O] . Rujuan Dai, Ran Lu, S Ansar Ahmed 2016

机译：小鼠狼疮中基因组印迹DLK1-Dio3 miRNa的上调与全球DNa低甲基化相关。

Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster

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