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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease
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Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease

机译：中国帕金森氏病患者的NURR1和PITX3基因表达降低

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Background and purpose: The preferential degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta is the pathological hallmark in Parkinson's disease (PD). The transcription factors NURR1 and PITX3 have been shown to play a crucial role in the maturation and survival of mDA neurons, and both of them were potential susceptibility genes for PD.Methods: To determine whether NURR1 and PITX3 gene expression are altered in Chinese patients with PD, we measured their gene expression in human peripheral blood lymphocytes (PBL) in 255 patients with PD and 211 age- and gender-matched healthy controls by quantitative real-time PCR technique.Results: We found that both NURR1 and PITX3 gene expression in PBL were significantly decreased in patients with PD as compared with controls (P < 0.0001). Lower levels of NURR1 and PITX3 gene expression were significantly associated with the increased risk for PD in male and older subjects, respectively. Conclusions: Our results provide useful information that the NURR1 and PITX3 gene expression is decreased in the PBL of Chinese patients with PD, indicating their possible systemic involvement in PD.
机译：背景与目的：黑质致密部中脑多巴胺能神经元的优先变性是帕金森氏病（PD）的病理标志。已经显示出转录因子NURR1和PITX3在mDA神经元的成熟和存活中起着至关重要的作用，它们都是PD的潜在易感基因。方法：确定中国DM患者的NURR1和PITX3基因表达是否发生改变通过定量实时PCR技术，我们检测了255名PD患者和211名年龄和性别相匹配的健康对照者的PD在人外周血淋巴细胞（PBL）中的基因表达。结果：我们发现NURR1和PITX3基因表达与对照组相比，PD患者的PBL显着降低（P <0.0001）。较低的NURR1和PITX3基因表达水平分别与男性和老年受试者发生PD的风险增加显着相关。结论：我们的结果提供了有用的信息，即中国PD患者的PBL中NURR1和PITX3基因表达降低，表明他们可能全身性参与PD。

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