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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Nigral iron deposition occurs across motor phenotypes of Parkinson's disease
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Nigral iron deposition occurs across motor phenotypes of Parkinson's disease

机译：帕金森氏病的运动表型发生黑色素铁沉积

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Background and purpose: To investigate whether brain iron deposition correlates with motor phenotypic expressions of Parkinson's disease. Methods: We subtyped patients with Parkinson's disease according to their main motor symptoms (tremor, rigidity/bradykinesia) into three subgroups: tremor-dominant subgroup, akinetic/rigid-dominant subgroup, or mixed subgroup. The iron levels in bilateral substantia nigra, globus pallidus, putamen, the head of caudate, and red nucleus of 87 patients and 50 control subjects were assayed by measuring phase values using susceptibility-weighted phase imaging in a 3-tesla magnetic resonance system. The serum ceruloplasmin levels of all subjects were determined. Results: The bilateral average phase values of the substantia nigra and all other brain regions examined did not correlate with the main motor symptoms of Parkinson's disease in the total patient group or when patients were grouped according to serum ceruloplasmin levels. Significant correlations between serum ceruloplasmin levels and nigral bilateral average phase values were observed in the tremor and akinetic/rigid-dominant subgroups. Analysis of patients without prior dopaminergic medication exhibited similar results. Increased nigral iron content correlated with disease severity as assayed by the Unified Parkinson's Disease Rating Scale motor scores in the PD AR subgroup. Conclusions: These findings suggest that nigral iron deposition, correlating with decreased serum ceruloplasmin levels, is a risk factor in Parkinson's disease across multiple motor phenotypic expressions.
机译：背景与目的：研究脑铁沉积与帕金森氏病的运动表型表达是否相关。方法：我们根据主要运动症状（震颤，僵硬/运动迟缓）将帕金森氏病患者分为三个亚组：以震颤为主的亚组，以运动/刚性为主的亚组或混合亚组。通过在3-特斯拉磁共振系统中使用磁化加权相成像测量相值，测定了87位患者和50名对照受试者的双侧黑质，苍白球，壳核，尾状头和红核中的铁水平。测定所有受试者的血清铜蓝蛋白水平。结果：在整个患者组中或根据血清铜蓝蛋白水平对患者进行分组时，黑质和所有其他大脑区域的双侧平均相位值与帕金森氏病的主要运动症状无关。在震颤和运动/刚性为主的亚组中观察到血清铜蓝蛋白水平与黑质双侧平均相值之间存在显着相关性。先前未接受多巴胺能药物治疗的患者的分析结果相似。通过PD AR子组中的统一帕金森氏疾病评分量表运动评分分析，增加的黑色铁含量与疾病严重程度相关。结论：这些发现表明，与多种运动表型表达有关的帕金森氏病是与血清铜蓝蛋白水平降低相关的黑质铁沉积。

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