...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Association between multiple sclerosis and chronic periodontitis: A population-based pilot study
【24h】

Association between multiple sclerosis and chronic periodontitis: A population-based pilot study

机译：多发性硬化症与慢性牙周炎之间的关联：一项基于人群的初步研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose: The pathogenesis of multiple sclerosis (MS) is still not fully understood, but multiple infections are known to be crucial in the development of the disease. Periodontitis caused by periodontopathic polymicrobial infections is among the most common chronic infectious disorders. This case-control study aimed to investigate the association between chronic periodontitis (CP) and MS using a population-based dataset in Taiwan. Methods: This study included 316 cases who had a diagnosis of MS and 1580 randomly selected controls. We performed conditional logistic regressions to investigate the association between MS and having been previously diagnosed with CP. Results: The results reveal that the prevalence of earlier CP was 25.6% and 15.4% for cases and controls, respectively (P<0.001). Conditional logistic regression analysis revealed that cases were 1.86 [95% confidence interval (CI)=1.39-2.48] times as likely as controls to have been previously diagnosed with CP, after adjusting for sociodemographic characteristics as well as hyperlipidemia, hypertension, coronary heart disease, alcohol abuse/alcohol-dependence syndrome, tobacco use disorder and chronic obstructive pulmonary disease. After analyzing by gender, it was realized that while female cases had a higher chance than female controls of having earlier CP (adjusted odds ratio =2.08; 95% CI=1.49-2.95), there was no statistical association detected between these two conditions in men. Conclusions: This study provides evidence for an association between CP and MS in female, but not male, subjects. Further epidemiological studies are needed to confirm the association and gender-specific differences found in the present study.
机译：背景和目的：多发性硬化症（MS）的发病机理仍未完全了解，但已知多种感染在该病的发展中至关重要。由牙周病性微生物感染引起的牙周炎是最常见的慢性感染性疾病。这项病例对照研究旨在使用台湾地区基于人群的数据集来调查慢性牙周炎（MS）与MS之间的关联。方法：本研究包括316例诊断为MS的病例和1580例随机选择的对照。我们进行了条件逻辑回归分析，以调查MS与先前被诊断为CP的关系。结果：结果显示，病例和对照组的早期CP患病率分别为25.6％和15.4％（P <0.001）。条件Logistic回归分析显示，在调整了社会人口统计学特征以及高脂血症，高血压，冠心病后，病例先前诊断为CP的对照的可能性是对照的1.86 [95％置信区间（CI）= 1.39-2.48]倍，酗酒/酒精依赖综合症，烟草使用障碍和慢性阻塞性肺疾病。根据性别进行分析后，我们发现虽然女性病例比女性对照者有更早的CP机会更高（调整比值比= 2.08; 95％CI = 1.49-2.95），但是在这两种情况下，没有发现统计学关联。男人们结论：这项研究为女性而非男性受试者的CP和MS之间的关联提供了证据。需要进一步的流行病学研究，以确认本研究中发现的关联和性别差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号