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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Assessment of cognitive function in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization
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Assessment of cognitive function in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization

机译：成人出血性烟雾病患者无手术血运重建的认知功能评估

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Background and purpose: Due to controversial surgical treatment for hemorrhagic moyamoya disease (MMD), a large proportion of these patients chose conservative treatment. The aim of this study was to assess cognitive function in adult patients with hemorrhagic MMD who received no surgical revascularization. Methods: Twenty-six adult hemorrhagic MMD patients with only intraventricular hemorrhage (IVH) confirmed by positive computed tomography and magnetic resonance imaging scan, 20 patients with spontaneous IVH whose digital subtraction angiography results were negative, and 30 healthy controls were identified and matched for age, gender, education background and living area. Cognitive function was evaluated by Montreal Cognitive Assessment (MoCA). The non-parametric test was used for comparisons among the three groups. Results: No patient was confirmed cognitive dysfunction at the initial screening. Twenty-four (92%) cases presented mild cognitive impairment (MCI) after 1year. All the cases demonstrated MCI after 2years. The difference between cases and healthy controls was statistically significant at the second screening (P=0.000) and the third screening (P=0.000), as was that between cases and patients with spontaneous IVH at the second screening (P=0.000) and the third screening (P=0.000). In addition, there were significant decreases in all MoCA subscores (P=0.000) with special regards to delayed recall, visual space and executive function in cases compared with the other two groups. Moreover, significant differences were found in the subgroups of smoking (P=0.021) and Suzuki angiographic classification of MMD (P=0.030). Conclusions: Cognitive impairment is a long-term complication for adult hemorrhagic MMD patients who underwent conservative treatment.
机译：背景与目的：由于对出血性烟雾病（MMD）的手术治疗颇有争议，因此这些患者中有很大一部分选择了保守治疗。这项研究的目的是评估没有手术血运重建的成年MMD出血患者的认知功能。方法：26例经计算机断层扫描和磁共振成像扫描证实为仅脑室内出血（IVH）的成人出血性MMD患者，20例数字减影血管造影结果为阴性的自发IVH患者，30例健康对照者被确定并匹配年龄，性别，教育背景和居住区域。认知功能通过蒙特利尔认知评估（MoCA）进行评估。非参数检验用于三组之间的比较。结果：初筛时未确认患者认知功能障碍。 1年后有24例（92％）出现轻度认知障碍（MCI）。所有病例均在2年后表现出MCI。在第二次筛查（P = 0.000）和第三次筛查（P = 0.000）时，病例与健康对照之间的差异具有统计学意义，在第二次筛查（P = 0.000）和第二次筛查时自发IVH的病例与患者之间也是如此。第三次筛查（P = 0.000）。此外，与其他两组相比，所有MoCA子评分（P = 0.000）均显着下降，特别是在延迟召回，视觉空间和执行功能方面。此外，在吸烟亚组（P = 0.021）和MMD的铃木血管造影分类（P = 0.030）中发现了显着差异。结论：认知障碍是接受保守治疗的成人出血MMD患者的长期并发症。

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