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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Risk of accidental injuries amongst Parkinson disease patients
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Risk of accidental injuries amongst Parkinson disease patients

机译：帕金森氏病患者意外受伤的风险

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Background and purpose: To investigate the spectrum and risks of accidental injuries (AIs) amongst Parkinson disease (PD) patients. Methods: The participants comprised PD patients aged 50 years and older who were initially diagnosed between 2000 and 2009, and a comparison group of non-PD patients. The incidence rates of accidental injury types amongst PD and non-PD patients were calculated; hazard ratios were calculated and adjusted for comorbidities, using 95% confidence intervals (CIs) of developing such outcomes in PD patients. Results: In total, 4046 PD patients and 16 184 non-PD patients were followed over time. The PD patients demonstrated the following incidence rates and hazard ratios in comparison to the control cohort for accidental injuries: all injuries, 19.78 per 100 person-years (100 PYs), adjusted hazard ratio (HR) 1.30 (95% CI 1.24-1.36); head injury, 2.95 per 100 PYs, HR 1.88 (95% CI 1.64-2.15); bone fracture and dislocation, 4.61 per 100 PYs, HR 1.39 (95% CI 1.25-1.54); burns, 0.66 per 100 PYs, HR 1.01 (95% CI 0.78-1.32); injury to spinal cord, plexus and nerves, 0.15 per 100 PYs, HR 1.25 (95% CI 0.72-2.17); superficial injuries and contusions, 11.41 per 100 PYs, HR 1.20 (95% CI 1.12-1.27). The injury risk for the 69-79 years age group in PD compared with controls of the same age (HR 1.38) was significantly higher compared with that of the 50-69 age groups in PD and controls (HR 1.16). Conclusions: Parkinson disease patients demonstrate a significantly elevated risk of developing all accidental injury types except burn injuries and injuries to spinal cord, plexus and nerves, compared with age-matched controls. The risk increases as age increases.
机译：背景与目的：研究帕金森病（PD）患者中意外伤害（AI）的范围和风险。方法：参与者包括最初在2000年至2009年之间被诊断为年龄在50岁以上的PD患者，以及一个非PD患者的对照组。计算PD和非PD患者中意外伤害类型的发生率;使用PD患者中此类结果的95％置信区间（CI）计算并调整合并症的危险比。结果：随着时间的推移，总共随访了4046名PD患者和16 184名非PD患者。与意外伤害对照组相比，PD患者表现出以下发病率和危险比：所有伤害，每100人年19.78（100 PYs），调整后的危险比（HR）1.30（95％CI 1.24-1.36） ;头部受伤，每100 PY 2.95，HR 1.88（95％CI 1.64-2.15）;骨折和脱位，每100 PYs为4.61，HR为1.39（95％CI 1.25-1.54）;灼伤，每100 PY 0.66，HR 1.01（95％CI 0.78-1.32）;脊髓，神经丛和神经损伤，每100 PY 0.15，HR 1.25（95％CI 0.72-2.17）;浅表伤害和挫伤，每100 PYs 11.41，HR 1.20（95％CI 1.12-1.27）。与相同年龄的对照组（HR 1.38）相比，PD的69-79岁年龄组的受伤风险显着高于PD和对照组的50-69岁年龄组（HR 1.16）。结论：与年龄匹配的对照组相比，帕金森病患者表现出发生除烧伤和脊髓，神经丛和神经损伤以外的所有意外伤害类型的风险显着升高。风险随着年龄的增长而增加。

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