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首页> 外文期刊>European journal of nutrition >Dietary fiber reduces the antioxidative effect of a carotenoid andalpha-tocopherol mixture on LDL oxidation ex vivo in humans
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Dietary fiber reduces the antioxidative effect of a carotenoid andalpha-tocopherol mixture on LDL oxidation ex vivo in humans

机译：膳食纤维降低人体内类胡萝卜素和α-生育酚混合物对LDL氧化的抗氧化作用

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Background: Antioxidant concentrations in low density lipoproteins (LDL) are an important determinant for their susceptability to oxidation and can be modulated by dietary intake. Aim of the study: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated. Method: An antioxidant supplement consisting of p-carotene, lycopene, lutein, canthaxanthin and a-tocopherol was given to six young women together with a standard meal. Using a cross-over study design, each subject received the standard meal without additional dietary fiber and enriched with pectin, guar, or cellulose in a random order. To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured. Results: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase. Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without. On average, pectin, guar, and cellulose reduced the increase of the lag phase (measured without addition of dietary fiber) by 38%, 21%, and 18%, respectively. Conclusions: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and a-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.
机译：背景：低密度脂蛋白（LDL）中的抗氧化剂浓度是决定其氧化敏感性的重要决定因素，可以通过饮食摄入来调节。研究目的：在本研究中，研究膳食纤维对补充抗氧化剂后LDL的抗氧化剂富集和抗氧化性的影响。方法：六名年轻妇女与一顿标准餐一起服用了由对-胡萝卜素，番茄红素，叶黄素，角黄素和α-生育酚组成的抗氧化剂补充剂。使用交叉研究设计，每个受试者均接受标准膳食，不含额外的膳食纤维，并以随机顺序富含果胶，瓜尔胶或纤维素。为了确定LDL对铜离子诱导的氧化的抵抗力，测量了共轭二烯的形成。结果：补充抗氧化剂后第8、10和24小时，分离的LDL显着（p <0.05）增加了抗氧化剂的浓度;在膳食中添加果胶，瓜尔胶或纤维素可抑制这种增加。同时，补充膳食纤维对LDL的抗氧化性（以滞后相测量）的增加比未观察到的低。平均而言，果胶，瓜尔胶和纤维素分别将滞后阶段（未添加膳食纤维的测量）的增加分别降低了38％，21％和18％。结论：这些结果表明，膳食纤维补充剂可降低低密度脂蛋白中由类胡萝卜素和α-生育酚组成的补充剂的抗氧化作用，这种作用可能是由于肠道中这些抗氧化剂的生物利用度降低所介导的。

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