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首页> 外文期刊>European Journal of Nuclear Medicine and Molecular Imaging >EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy.
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EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy.

机译：EANM剂量学委员会系列关于治疗前剂量学I的标准操作程序系列：分化型甲状腺癌治疗中的血液和骨髓剂量学。

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INTRODUCTION: The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Pre-therapeutic Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform pre-therapeutic and/or therapeutic patient-specific absorbed dose assessments. MATERIAL AND METHODS: This particular SOP gives advice on how to tailor the therapeutic activity to be administered for systemic treatment of differentiated thyroid cancer (DTC) such that the absorbed dose to the blood does not exceed 2 Gy (a widely accepted limit for bone marrow toxicity). The methodology of blood-based dosimetry has been developed in the 1960s and refined in a series of international multi-centre trials in the framework of the introduction of new diagnostic and therapeutic tools, e.g. recombinant human thyroid-stimulating hormone in the management of DTC. CONCLUSION: The intention is to guide the user through a series of measurements and calculations which the authors consider to be the best and most reproducible way at present.
机译：简介：关于“治疗前剂量学的标准操作程序”（SOP）的EANM剂量学委员会系列的目的是为科学家和临床医生提供有关如何进行治疗前和/或治疗性患者特定吸收剂量评估的建议。材料与方法：该特殊SOP为如何定制全身性分化型甲状腺癌（DTC）的治疗活性提供了建议，以使血液吸收剂量不超过2 Gy（骨髓公认的极限）毒性）。基于血液的剂量测定方法已于1960年代开发，并在引入新的诊断和治疗工具（例如注射用药）的框架内的一系列国际多中心试验中得到了完善。重组人促甲状腺激素在DTC的管理中。结论：目的是通过一系列测量和计算来指导用户，作者认为这是目前最好和最可重复的方法。

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