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首页> 外文期刊>European journal of nutrition >Blood glucose concentrations and breast cancer risk in women without diabetes: a meta-analysis.
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Blood glucose concentrations and breast cancer risk in women without diabetes: a meta-analysis.

机译：没有糖尿病的女性的血糖浓度和患乳腺癌的风险：一项荟萃分析。

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Purpose: Some studies have suggested an increased risk of breast cancer associated with elevated fasting serum glucose in nondiabetic subjects. Given how common both breast cancer and impaired glucose tolerance are in our aging societies, this is an important issue for public health. Methods: We performed a systematic review of prospective cohort studies that examined the association between elevated serum glucose levels in nondiabetic subjects (levels below 7.0 mml/L) and the subsequent risk of breast cancer. We performed a systematic literature search and extracted relevant data in a standard way. We then computed summary relative risks (SRR) and 95% confidence intervals using a random effects model applied on the risk of highest versus lowest quantile of serum glucose concentrations. Results: Ten cohort studies were retrieved. The SRR for all studies was 1.11 (1.00-1.23), with no evidence of heterogeneity or publication bias. The SRR was not affected when the analysis was restricted to the 8 studies that reported results for fasting subjects (SRR=1.11; 95% CI 0.98-1.25). Three studies provided BMI-unadjusted and BMI-adjusted SRRs of 1.24 (95% CI 0.60-2.56) and 1.20 (95% CI 0.63-2.27), respectively. Similar magnitudes of associations were observed in sensitivity analyses, but statistical significance was lost. Conclusion: In nondiabetic subjects, the risk of breast cancer associated with fasting serum glucose levels seems to be small. Potential limitations to this meta-analysis include the fact that not all studies reported risks adjusted for adiposity and that serum glucose levels of comparison groups were variable across studies.
机译：目的：一些研究表明，非糖尿病受试者中与空腹血糖升高相关的乳腺癌风险增加。考虑到我们的老龄化社会中乳腺癌和葡萄糖耐量减低的普遍性，这是公共卫生的重要问题。方法：我们对前瞻性队列研究进行了系统的综述，该研究检查了非糖尿病受试者的血糖水平升高（低于7.0 mml / L）与随后患乳腺癌的风险之间的关系。我们进行了系统的文献检索，并以标准方式提取了相关数据。然后，我们使用随机效应模型计算了最高相对于最低血糖浓度风险的最低相对风险（SRR）和95％置信区间。结果：检索了十项队列研究。所有研究的SRR为1.11（1.00-1.23），没有证据表明异质性或发表偏倚。当分析仅限于8项报告禁食受试者结果的研究时（SRR = 1.11; 95％CI 0.98-1.25），SRR不受影响。三项研究分别提供未经BMI调整和经BMI调整的SRR分别为1.24（95％CI 0.60-2.56）和1.20（95％CI 0.63-2.27）。在敏感性分析中观察到相似的关联程度，但统计学意义消失了。结论：在非糖尿病受试者中，与空腹血糖水平相关的乳腺癌风险似乎很小。这项荟萃分析的潜在局限性包括以下事实：并非所有研究都报告了针对肥胖症进行调整的风险，并且各研究组之间的比较组血清葡萄糖水平存在差异。

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