...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Nuclear Medicine and Molecular Imaging >Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: Comparison of brain SPECT and PET imaging
【24h】

Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: Comparison of brain SPECT and PET imaging

机译：交叉小脑灌注不足检测慢性单侧主要脑动脉狭窄闭塞性疾病在脑半球的痛苦灌注：脑SPECT和PET成像的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: In patients with unilateral internal carotid or middle cerebral artery (ICA or MCA) occlusive disease, the degree of crossed cerebellar hypoperfusion that is evident within a few months after the onset of stroke may reflect cerebral metabolic rate of oxygen in the affected cerebral hemisphere relative to that in the contralateral cerebral hemisphere. The aim of the present study was to determine whether the ratio of blood flow asymmetry in the cerebellar hemisphere to blood flow asymmetry in the cerebral hemisphere on positron emission tomography (PET) and single photon emission computed tomography (SPECT) correlates with oxygen extraction fraction (OEF) asymmetry in the cerebral hemisphere on PET in patients with chronic unilateral ICA or MCA occlusive disease and whether this blood flow ratio on SPECT detects misery perfusion in the affected cerebral hemisphere in such patients. Methods: Brain blood flow and OEF were assessed using 15O-PET and N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) SPECT, respectively. All images were anatomically standardized using SPM2. A region of interest (ROI) was automatically placed in the bilateral MCA territories and in the bilateral cerebellar hemispheres using a three-dimensional stereotaxic ROI template, and affected-to-contralateral asymmetry in the MCA territory or contralateral-to-affected asymmetry in the cerebellar hemisphere was calculated. Sixty-three patients with reduced blood flow in the affected cerebral hemisphere on 123I-IMP SPECT were enrolled in this study. Results: A significant correlation was observed between MCA ROI asymmetry of PET OEF and the ratio of cerebellar hemisphere asymmetry of blood flow to MCA ROI asymmetry of blood flow on PET (r=0.381, p=0.0019) or SPECT (r=0.459, p=0.0001). The correlation coefficient was higher when reanalyzed in a subgroup of 43 patients undergoing a PET study within 3 months after the last ischemic event (r=0.541, p=0.0001 for PET; r=0.609, p0.0001 for SPECT). The blood flow ratio on brain perfusion SPECT in all patients provided 100 % sensitivity and 58 % specificity, with 43 % positive and 100 % negative predictive values for detecting abnormally elevated MCA ROI asymmetry of PET OEF. Conclusion: The ratio of blood flow asymmetry in the cerebellar hemisphere to blood flow asymmetry in the cerebral hemisphere on PET and SPECT correlates with PET OEF asymmetry in the cerebral hemisphere, and this blood flow ratio on SPECT detects misery perfusion in the affected cerebral hemisphere.
机译：目的：在患有单侧颈内动脉或大脑中动脉（ICA或MCA）闭塞性疾病的患者中，中风发作后几个月内出现的小脑交叉灌注不足的程度可能反映了患病的大脑半球中脑氧的新陈代谢率相对于对侧大脑半球。本研究的目的是确定正电子发射断层显像（PET）和单光子发射计算机断层显像（SPECT）上小脑半球的血流不对称与脑半球的血流不对称之比是否与氧提取分数相关（ OEF）在患有慢性单侧ICA或MCA闭塞性疾病的患者中，PET在脑半球中的不对称性以及SPECT上的这种血流比是否检测到了此类患者在受影响的大脑半球中的痛苦灌注。方法：分别使用15O-PET和N-异丙基-对-[123I]碘安非他命（123I-IMP）SPECT评估脑血流量和OEF。所有图像均使用SPM2进行了解剖学标准化。使用三维立体定向ROI模板，将感兴趣的区域（ROI）自动放置在双侧MCA区域和双侧小脑半球中，并且MCA区域中受影响对侧的不对称性或对侧对受影响的不对称性计算了小脑半球。本研究纳入了123I-IMP SPECT上受影响的大脑半球血流减少的63例患者。结果：PET OEF的MCA ROI不对称性与小脑半球不对称率与PET（r = 0.381，p = 0.0019）或SPECT（r = 0.459，p = 0.0001）。在最后一次缺血事件后3个月内对43位接受PET研究的患者亚组重新分析时，相关系数更高（r = 0.541，p = 0.0001（PET）; r = 0.609，p <0.0001）。在所有患者中，脑灌注SPECT的血流比提供100％的敏感性和58％的特异性，其中43％的阳性和100％的阴性预测值可用于检测PET OEF的MCA ROI不对称异常升高。结论：PET和SPECT上小脑半球的血流不对称率与脑半球中的血流不对称率之比与脑半球中PET OEF的不对称性有关，SPECT上的该血流率可检测患部大脑半球的痛苦灌注。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号