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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Relevance of 10-min delayed recall in dementia screening.
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Relevance of 10-min delayed recall in dementia screening.

机译：痴呆症筛查中延迟回忆10分钟的相关性。

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摘要

Within the context of early diagnosis of Alzheimer's disease (AD), there is a growing interest in neuropsychological screening tests. Amongst these tests, we focused on the largely used Memory Impairment Screen (MIS). The objective of the present work was to show that adding a 10-min delayed recall to the MIS, improves the test psychometric characteristics in order to detect dementia in the earliest stages. A prospective study was carried out on a cohort of 270 consecutive elderly ambulatory subjects attending the Broca Hospital Memory Clinic: normal controls (n = 67), mild cognitive impairment subjects (n = 98) and mildly demented patients [n = 105, Mini Mental State Examination (MMSE) = 23 +/- 4]. This study consisted in testing the advantage of the 10-min delayed recall entitled MIS-D compared with the MIS. At a cut-off score of 6, the MIS-D revealed satisfying psychometric characteristics with a sensitivity of 81% and a specificity of 91%, whilst the MIS alone indicated a sensitivity of 60% and a specificity of 88% in detecting dementia. In demented patients with MMSE score > or =26, MIS-D properties still remained satisfying (sensitivity: 75%, specificity: 92%). MIS-D is a more relevant screening test than MIS alone at very early stages of dementia.
机译：在阿尔茨海默氏病（AD）的早期诊断的背景下，人们对神经心理学筛查测试的兴趣与日俱增。在这些测试中，我们集中于广泛使用的内存受损屏幕（MIS）。本工作的目的是表明，向MIS添加10分钟的延迟回忆，可以改善测试心理计量学特征，以便尽早发现痴呆症。对参加Broca医院记忆诊所的270名连续的老年门诊患者进行了一项前瞻性研究：正常对照（n = 67），轻度认知障碍患者（n = 98）和轻度痴呆患者[n = 105，迷你精神病患者状态考试（MMSE）= 23 +/- 4]。这项研究包括测试与MIS相比，名为MIS-D的10分钟延迟召回的优势。截止得分为6，MIS-D表现出令人满意的心理测量特征，灵敏度为81％，特异性为91％，而MIS单独表明在检测痴呆症中的灵敏度为60％，特异性为88％。在MMSE评分>或= 26的痴呆患者中，MIS-D特性仍然令人满意（敏感性：75％，特异性：92％）。与痴呆症早期阶段的单独MIS相比，MIS-D是更相关的筛查测试。

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