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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >The neuroprotection of prodromal transient ischaemic attack on cerebral infarction.
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The neuroprotection of prodromal transient ischaemic attack on cerebral infarction.

机译：前驱短暂性脑缺血发作对脑梗死的神经保护作用。

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摘要

BACKGROUND AND PURPOSE: To evaluate the potential neuroprotection against subsequent cerebral infarction conferred by a prodromal transient ischaemic attack (TIA). METHODS: Various measures, including blood pressure, blood serum glucose, serum lipids, cardiovascular imaging and changes to NIHSS scores were evaluated upon admission and discharge for patients presenting with ischaemic stroke with or without prodromal TIA (n = 60 per group). RESULTS: When all patients from each group were considered together, no significant group effects emerged. However, when the NIHSS difference scores from the prodromal TIA group were subdivided based on (i) prodromal TIA lasting up to 4 min; (ii) two prodromal TIA attacks and/or; (iii) prodromal TIA-stroke interval within 7 days separately, patients in subgroups 1 and 2 exhibited significantly better outcome on discharge. There was no significant effect found in subgroup three although this TIA group did show better outcome in considering the NIHSS changes. CONCLUSIONS: Prodromal TIA prior to cerebral infarction may result in an ischaemic tolerance effect. Moreover, the neuroprotection conferred by the TIA may be associated with the duration and the frequency of the TIA, although the relationship between the TIA-stroke interval and prognosis is not clear.
机译：背景和目的：评估潜在的神经保护作用，以预防前驱性短暂性脑缺血发作（TIA）继发的脑梗塞。方法：对有缺血性卒中伴或不伴前驱性TIA的患者入院和出院时评估血压，血糖，血脂，心血管成像和NIHSS评分变化等各种指标（每组n = 60）。结果：将每组的所有患者一起考虑时，没有出现明显的组效应。但是，当根据前驱性TIA组的NIHSS差异评分进行细分时：（i）前驱性TIA持续4分钟; （ii）两次TIA前驱攻击和/或; （iii）前驱性TIA卒中间隔分别在7天内，亚组1和2的患者出院时表现出明显更好的结局。尽管该TIA组在考虑NIHSS改变时确实显示出更好的结局，但在第三亚组中未发现明显的作用。结论：脑梗死之前的前驱性TIA可能导致局部缺血耐受。此外，尽管TIA卒中间隔与预后之间的关系尚不清楚，但TIA赋予的神经保护作用可能与TIA的持续时间和频率有关。

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