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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Revascularization in acute ischaemic stroke using the penumbra system: the first single center experience.
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Revascularization in acute ischaemic stroke using the penumbra system: the first single center experience.

机译：使用半影系统进行急性缺血性卒中的血运重建：首次单中心经验。

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BACKGROUND AND PURPOSE: This is the first single center experience illustrating the effectiveness of the penumbra system (PS) in the treatment of large vessel occlusive disease in the arena of acute ischaemic stroke. The PS is an innovative mechanical thrombectomy device, employed in the revascularization of large cerebral vessel occlusions in patients via the utilization of an aspiration platform. METHODS: This is a prospective, non-randomized controlled trial evaluating the clinical and functional outcome in 29 patients with acute intra-cranial occlusions consequent to mechanical thrombectomy by the PS either as mono-therapy or as an adjunct to current standard of care. Patients were evaluated by a neurologist and treated by our in house interventional neuro-radiologists. Primary end-points were revascularization of the occluded target vessel to TIMI grade 2 or 3 and neurological outcome as measured by an improvement in the NIH Stroke Scale (NIHSS) score after the procedure. RESULTS: Complete revascularization (TIMI 3) was achieved in 21/29 (72.4%) of patients. Partial revascularization (TIMI 2) was established in 4/29 (13.8%) of patients. Revascularization failed in four (13.8%) patients. Nineteen (19) patients (65.5%) had at least a four-point improvement in NIHSS scores. Modified Rankin scale scores of < or =2 were seen in 37.9% of patients. There were no device-related adverse events. Symptomatic intra-cranial hemorrhage occurred in 7% of patients. CONCLUSIONS: The PS has the potential of exercising a significant impact in the interventional treatment of ischaemic stroke in the future.
机译：背景与目的：这是首次单中心经验，阐明了半影系统（PS）在急性缺血性卒中领域中治疗大血管闭塞性疾病的有效性。 PS是一种创新的机械血栓切除术设备，用于通过利用抽吸平台对患者的大型脑血管阻塞进行血运重建。方法：这是一项前瞻性，非随机对照试验，评估了29例因PS进行机械血栓切除术而导致的急性颅内阻塞的患者的临床和功能结局，作为单一疗法或作为当前护理标准的辅助手段。患者由神经科医生评估，并由我们的内部介入神经放射科医生进行治疗。主要终点是阻塞的靶血管血运重建至TIMI 2或3级，并通过手术后NIH卒中量表（NIHSS）评分的改善来衡量神经系统结局。结果：21/29（72.4％）的患者实现了完全血运重建（TIMI 3）。在4/29（13.8％）的患者中建立了部分血运重建（TIMI 2）。四名（13.8％）患者的血运重建失败。十九（19）名患者（65.5％）的NIHSS评分至少提高了4分。在37.9％的患者中，修正的Rankin量表评分小于或等于2。没有与设备相关的不良事件。 7％的患者出现症状性颅内出血。结论：PS有可能在将来对缺血性中风的介入治疗中产生重大影响。

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