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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Low ankle-brachial index is a predictive factor for initial severity of acute ischaemic stroke
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Low ankle-brachial index is a predictive factor for initial severity of acute ischaemic stroke

机译：低踝肱指数是急性缺血性卒中初期严重程度的预测因素

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Background: A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients with and without PAD. Thus, we investigated whether a low ABI was associated with severe stroke presentation.Methods: We enrolled 1147 first-ever ischaemic stroke patients who underwent ABI measurements during hospitalization. Patients were categorized into the normal (> 0.90) or the abnormal (< 0.90) ABI group. Baseline characteristics and initial National Institutes of Health Stroke Scale (NIHSS) scores were compared between the groups. We further analysed components of the NIHSS subscales in these groups. Results: Ankle-brachial index was abnormal in 85 (7.4%) patients. Mean initial NIHSS score was higher in the abnormal ABI group (6.61 +- 6.56) than in the normal ABI group (4.36 +- 4.90) (P = 0.003). A low ABI was independently associated with higher NIHSS score in a multivariate analysis. In the abnormal ABI group, leg weakness was more severe than it was in the normal ABI group, and the contribution of leg weakness to the initial NIHSS score was higher.Conclusions: Patients with low ABI values presented with more severe ischaemic stroke. Contribution of pre-existing PAD to leg weakness may play a role in the initial severity of stroke in patients with PAD. Our findings suggest that poor clinical outcomes in patients with PAD may be partially explained by their increased likelihood for severe stroke.
机译：背景：踝臂指数低（ABI）可以预测外周动脉疾病（PAD）。出于未知原因，PAD患者在随访期间的血管死亡率要高于无PAD的患者。初始卒中严重程度是长期预后的有力预测指标，有和没有PAD的患者之间可能有所不同。因此，我们调查了低ABI是否与严重的中风表现有关。方法：我们招募了1147例首次住院期间接受过ABI测量的缺血性中风患者。将患者分为正常（> 0.90）或异常（<0.90）ABI组。比较两组之间的基线特征和美国国立卫生研究院卒中量表（NIHSS）评分。我们进一步分析了这些组中NIHSS分量表的组成部分。结果：85（7.4％）患者的踝臂指数异常。异常ABI组（6.61±6.56）的平均初始NIHSS评分高于正常ABI组（4.36±4.90）（P = 0.003）。在多变量分析中，较低的ABI与较高的NIHSS得分独立相关。 ABI异常组的腿无力比正常ABI组更严重，并且腿无力对初始NIHSS评分的贡献更高。结论：ABI值低的患者表现为更严重的缺血性中风。先前存在的PAD对腿部无力的贡献可能在PAD患者的中风初始严重程度中起作用。我们的发现表明，PAD患者的临床预后较差可能部分是由于他们发生严重中风的可能性增加所致。

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