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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis
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Alcohol, coffee, fish, smoking and disease progression in multiple sclerosis

机译：酒精，咖啡，鱼，吸烟和多发性硬化症的疾病进展

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Background: Certain lifestyle factors might influence disease activity in multiple sclerosis (MS). Objectives: To investigate the consumption of alcoholic beverages, caffeinated drinks, fish and cigarette smoking in relation to disability progression in relapsing onset and progressive onset MS. Methods: We conducted a cross-sectional survey amongst individuals with MS, registered by the Flemish MS society in Belgium. A time-to-event analysis and Cox proportional-hazard regression were performed with time to Expanded Disability Status Scale (EDSS) 6 (requiring a cane or support to walk for a distance of 100m) as outcome measure. Hazard ratios for the time from onset and from birth were adjusted for age at onset, gender and immunomodulatory treatment. Results: Data of 1372 persons with definite MS were collected. In the relapsing onset group, a decreased risk for reaching EDSS 6 was found in regular consumers of alcohol, wine, coffee and fish compared with those who never consumed these substances. Cigarette smoking was associated with an enhanced risk for reaching EDSS 6. In the progressive onset group, no association with the risk of reaching EDSS 6 was found, except for the type of fish. Preference for fatty fish was associated with an increased risk to reach EDSS 6, when lean fish was taken as the reference category. Conclusion: Consumption of alcoholic beverages, coffee and fish were inversely associated with progression of disability in relapsing onset MS, but not in progressive onset MS. These findings allow to support the hypothesis that different mechanisms might underlie progression of disability in relapsing and progressive onset MS.
机译：背景：某些生活方式因素可能会影响多发性硬化症（MS）中的疾病活动。目的：调查酒精饮料，含咖啡因的饮料，鱼类和香烟的吸烟与复发性MS和进行性MS发病中残障进展的关系。方法：我们对比利时佛兰芒MS协会注册的MS患者进行了横断面调查。对事件进行时间分析和Cox比例风险回归，并以扩展的残疾状态量表（EDSS）6（要求拐杖或支撑物行走100m的距离）作为结果度量。根据发病年龄，性别和免疫调节治疗，调整发病和出生时的危险比。结果：收集了1372名MS确诊患者的数据。在复发性发作组中，经常饮酒，喝酒，喝咖啡和吃鱼的人与从未喝过这些物质的人相比，达到EDSS 6的风险降低。吸烟与达到EDSS 6的风险增加有关。在进行性发作组中，除鱼的种类外，未发现与达到EDSS 6的风险相关。当将瘦鱼作为参考类别时，偏爱肥鱼会增加达到EDSS 6的风险。结论：酒精饮料，咖啡和鱼的摄入与复发性MS的残疾进展呈负相关，而与进行性MS无关。这些发现可以支持这样的假说，即在复发性和进行性MS发病过程中，残疾机制可能是不同机制的基础。

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