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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Vascularization of carotid plaque in recently symptomatic patients is associated with the occurrence of transcranial microembolic signals
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Vascularization of carotid plaque in recently symptomatic patients is associated with the occurrence of transcranial microembolic signals

机译：最近有症状的患者颈动脉斑块的血管化与经颅微栓塞信号的发生有关

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Background and purpose: Microembolic signals (MES) are detectable in the middle cerebral artery by transcranial ultrasound downstream to atherosclerotic lesions of the internal carotid artery (ICA) in patients with stroke or transient ischaemic attack. The occurrence of MES predicts future risk of stroke in patients with symptomatic and asymptomatic carotid stenosis. The detection of intra-plaque neo-vascularization by contrast-enhanced ultrasound (CEUS) in atherosclerotic plaques of the ICA is associated with future cardiovascular/cerebrovascular events. We investigated whether there is an association between both surrogate markers of future vascular events. Methods: Forty-one patients with symptomatic atherosclerotic plaques underwent ipsilateral transcranial ultrasound MES detection for 30min followed by a CEUS investigation of the plaque. The occurrence and number of MES was documented, and the degree of intra-plaque neo-vascularization was measured semi-quantitatively. Results: During the 30min investigation, 17 patients had MES and nine of them showed neo-vascularization of the atherosclerotic plaque. The remaining 24 patients did not have MES, and only in four patients of this group could plaque neo-vascularization be demonstrated (P=0.020). Conclusions: We found an association between the occurrence of MES and the presence of neo-vascularization in patients with symptomatic atherosclerotic carotid plaque. Therefore, plaque neo-vascularization might also be a surrogate marker of future stroke risk.
机译：背景与目的：对于患有中风或短暂性脑缺血发作的患者，通过颈内动脉（ICA）动脉粥样硬化病变的下游经颅超声可在大脑中动脉检测到微栓塞信号（MES）。 MES的发生预示着有症状和无症状的颈动脉狭窄患者的中风风险。通过对比增强超声（CEUS）检测ICA的动脉粥样硬化斑块中的斑块内新血管形成与未来的心血管/脑血管事件有关。我们调查了未来血管事件的两个替代指标之间是否存在关联。方法：对有症状的动脉粥样硬化斑块的41例患者进行同侧经颅超声MES检测30分钟，然后对斑块进行CEUS检查。记录MES的发生和数量，并半定量测量斑块内新血管形成的程度。结果：在30分钟的调查中，有17例患者患有MES，其中9例显示了动脉粥样硬化斑块的新血管形成。其余24例患者没有MES，并且该组中只有4例患者可显示出斑块状新血管形成（P = 0.020）。结论：我们发现有症状的动脉粥样硬化性颈动脉斑块患者的MES发生与新血管形成之间存在关联。因此，斑块新血管形成也可能是未来中风风险的替代标志。

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