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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Vitamin D for the prevention of stroke incidence and disability: Promising but too early for prime time
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Vitamin D for the prevention of stroke incidence and disability: Promising but too early for prime time

机译：预防中风发生和残疾的维生素D：前景广阔，但黄金时段还为时过早

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摘要

Vitamin D is a neurosteroid, with vitamin D receptors widely expressed in the brain, both in neuronal and glial cells. Genes encoding enzymes for both the metabolism and degradation of activated vitamin D [1,25(OH)2D or calcitriol] are also found in the brain [1]. Vitamin D may play a role in neuroprotection, perhaps through detoxification pathways, inhibition of inducible nitric oxide synthase, antioxidation/anti-infiammatory mechanisms, neuronal calcium regulation, or enhanced nerve conduction [1]. Vitamin D may also prevent vascular injury through-lowering blood pressure, inhibiting the renin-angiotensin-aldosterone system, and inhibiting atherogenesis [2].
机译：维生素D是一种神经甾体，在大脑的神经元和神经胶质细胞中广泛表达维生素D受体。在大脑中也发现了编码用于活化维生素D [1,25（OH）2D或骨化三醇]的代谢和降解的酶的基因[1]。维生素D可能通过排毒途径，抑制诱导型一氧化氮合酶，抗氧化/抗炎症机制，调节神经元钙或增强神经传导而在神经保护中起作用[1]。维生素D还可以通过降低血压，抑制肾素-血管紧张素-醛固酮系统和抑制动脉粥样硬化来预防血管损伤[2]。

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