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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis
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Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

机译：光学相干断层扫描不支持肌萎缩性侧索硬化的视神经受累

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Background and purpose: In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) - with its potential to reveal neuroaxonal retinal damage - may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. Methods: Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised. Results: There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity. Conclusions: These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS.
机译：背景与目的：近年来，肌萎缩性侧索硬化症（ALS）中神经系统可能的非运动性受累成为研究的焦点，并已通过多种技术进行了研究。光学相干断层扫描（OCT）-具有揭示神经轴突视网膜损害的潜力-可能是研究前路视觉通路是否参与的合适工具。我们的目的是确定基于OCT的视网膜神经纤维层，神经节细胞层，内核层和外核层厚度的测量值在ALS中是否异常，或与疾病的严重程度相关。方法：对76例ALS患者（144眼）和54例健康对照者（108眼; HCs）进行了OCT检查，包括自动视网膜内黄斑区分割。用肌萎缩性侧索硬化功能评定量表（修订版）确定ALS疾病的严重程度。结果：在所有检查的OCT措施中，ALS患者和HCs之间无显着差异。此外，OCT参数显示出与疾病严重程度的临床指标无关。结论：这些发现表明，前视觉通路的参与不是ALS的非运动表现之一。

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