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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course.
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CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course.

机译：CXCL10单倍型和多发性硬化：与临床过程的关联和相关性。

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摘要

CXCL10 (interferon-gamma-inducible protein-10) levels are increased in cerebrospinal fluid of multiple sclerosis (MS) patients with symptomatic attacks of inflammatory demyelination, supporting a role for this molecule in MS pathogenesis. Two hundred and twenty-six patients with MS and 235 controls were genotyped for G --> C and T --> C single nucleotide polymorphisms (SNPs) in exon 4 of CXCL10 gene. Haplotypes were tested for association and correlated with clinical variables. The two SNPs studied were in complete linkage disequilibrium. None of the determined haplotypes was associated with MS. However, carriers of the GGTT haplotype (defined as wild type, according to the sequence in National Centre for Biotechnology Information (NCBI) database) had a significantly lower progression index than non-carriers (P = 0.016). Furthermore, amongst patients who had an initial relapsing remitting (RR) course of the disease, the time between onset and second episode was significantly longer in GGTT carriers (P = 0.021). Considering secondary progressive (SP)-MS patients, the time between the initial RR form and the subsequent worsening to SP was longer in this group (P = 0.08). Therefore, the GGTT haplotype of the CXCL10 gene is not a susceptibility factor for the development of MS, but is probably to influence the course of MS, possibly contributing to slow down the progression of the disease.
机译：具有炎症性脱髓鞘症状发作的多发性硬化症（MS）患者的脑脊液中CXCL10（干扰素-γ诱导型蛋白10）水平升高，支持该分子在MS发病机理中的作用。对226例MS和235例对照患者的CXCL10基因外显子4的G-> C和T-> C单核苷酸多态性（SNP）进行基因分型。测试了单体型的关联性并与临床变量相关。研究的两个SNP处于完全连锁不平衡状态。没有确定的单倍型与MS相关。但是，GGTT单倍型（根据国家生物技术信息中心（NCBI）数据库中的序列定义为野生型）的携带者的进展指数明显低于非携带者（P = 0.016）。此外，在患有该疾病初始复发缓解（RR）病程的患者中，GGTT携带者的发病与第二次发作之间的时间明显更长（P = 0.021）。考虑到继发性进行性（SP）-MS患者，该组中从最初的RR形式到随后的SP恶化之间的时间更长（P = 0.08）。因此，CXCL10基因的GGTT单倍型不是MS发生的易感性因素，但可能影响MS的病程，可能有助于减慢疾病的进程。

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