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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease.
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Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease.

机译：特发性正常压力脑积水中的脑脊液tau，磷酸化tau181和β-淀粉样蛋白1-42：与阿尔茨海默氏病的区别。

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摘要

The aim of the present study was the quantitation of total tau protein (tau(T)), tau phosphorylated at threonine 181 (tau(P-181)) and beta-amyloid(1-42) (Abeta42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls. Double sandwich ELISAs (Innogenetics) were used for the measurements. Total tau was significantly increased in iNPH and highly increased in AD as compared with the control group, whilst Abeta42 was decreased in both diseases. CSF tau(P-181) levels were significantly increased only in AD, but not in iNPH as compared with the controls. A cut-off level for tau(T) at 300 pg/ml, successfully discriminated AD from normal aging with a 95.8% specificity and 91% sensitivity; whilst the tau(P-181)/tau(T) ratio (cut-off value 0.169) was more specific (100%) but less sensitive (92.5%). For the discrimination of iNPH from AD tau(T) achieved low specificity (77.8%) but high sensitivity (92.5%), whilst tau(P-181) (cut-offvalue 47.4) was both sensitive and specific (88.7% and 86.7% respectively) for the discrimination of these disorders. The present study, despite being clinical, supports the notion that CSF tau(P-181) alone or in combination with tau(T) may be a useful marker in the discrimination of iNPH from AD.
机译：本研究的目的是定量脑脊髓液中的总tau蛋白（tau（T）），在苏氨酸181（tau（P-181））和β-淀粉样蛋白（1-42）（Abeta42）磷酸化的tau。患有特发性正常压力脑积水（iNPH），阿尔茨海默氏病（AD）和对照的患者。使用双夹心ELISA（Innogenetics）进行测量。与对照组相比，iNPH中的总tau显着增加，而AD中的总tau则大大增加，而两种疾病中的Abeta42均降低。与对照组相比，仅在AD中CSF tau（P-181）水平显着升高，而在iNPH中则没有。 tau（T）的临界水平为300 pg / ml，以95.8％的特异性和91％的灵敏度成功地将AD与正常衰老区分开;而tau（P-181）/ tau（T）比率（临界值0.169）更具体（100％），但敏感性较低（92.5％）。为了区分AD中的iNPH，tau（T）的特异性低（77.8％）但敏感性高（92.5％），而tau（P-181）（临界值47.4）既灵敏又特异性（88.7％和86.7％）分别）以区分这些疾病。尽管有临床意义，本研究支持以下观点：单独或与tau（T）联合使用的脑脊液tau（P-181）可能是区分iNPH与AD的有用标志物。

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