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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Adjustment of treatment increases quality of life in patients with epilepsy: a randomized controlled pragmatic trial.
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Adjustment of treatment increases quality of life in patients with epilepsy: a randomized controlled pragmatic trial.

机译：调整治疗方法可提高癫痫患者的生活质量：一项随机对照的临床试验。

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BACKGROUND AND PURPOSE: Complaints about side-effects of antiepileptic drugs (AEDs) may be overlooked in clinical practice. We assessed the value and risks of an active intervention policy for reported complaints in a randomized controlled pragmatic trial. METHODS: This randomized controlled pragmatic trial included 111 adults treated for epilepsy in seven general hospitals. They were considered well-managed by their treating physician, but reported moderate to severe complaints on a questionnaire (SIDAED, assessing SIDe effects in AED treatment). The intervention was adjustment of AED treatment (53 patients), either reduction of dose or switch of AED, versus continuation of treatment unchanged (58 control patients) during 7 months. Primary outcomes were quality of life (Qolie-10) and complaints score. Secondary outcome measures were the occurrence of seizures or adverse events. RESULTS: After 7 months, the relative risk (RR) for improvement in quality of life was 1.80 (1.04-3.12) for the intervention group compared to control and the RR of decrease in complaints was 1.34 (0.88-2.05). In 58% of patients randomized to adjustment, the medication had indeed been changed. DISCUSSION: In conclusion, despite a possible risk of seizure recurrence, adjustment of drug treatment in well-managed patients with epilepsy, who report considerable complaints, improves the quality of life.
机译：背景与目的：有关抗癫痫药（AED）副作用的投诉在临床实践中可能会被忽略。我们在一项随机对照的临床试验中评估了主动干预政策对所报告投诉的价值和风险。方法：这项随机对照的临床试验纳入了7所综合医院的111名接受癫痫治疗的成人。他们的主治医生认为他们管理良好，但在调查表中报告了中度至严重的不适（SIDAED，评估了AED治疗中SIDe的作用）。干预是在7个月内调整AED治疗（53例患者），减少AED剂量或改变AED相对于继续治疗不变（58例对照患者）。主要结果是生活质量（Qolie-10）和投诉评分。次要结果指标是癫痫发作或不良事件的发生。结果：干预组在7个月后，生活质量改善的相对风险（RR）为1.80（1.04-3.12），而投诉减少的相对风险（RR）为1.34（0.88-2.05）。在58％随机调整的患者中，药物确实已更换。讨论：总而言之，尽管癫痫复发的可能性很大，但对有好主意的癫痫患者进行药物治疗的调整后，他们的生活质量得到改善。

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