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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark
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Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark

机译：丹麦幽门螺杆菌感染的治疗和帕金森氏病的风险

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Background and purpose: It has been speculated that gastrointestinal infection with Helicobacter pylori (HP) contributes to the development of Parkinson's disease (PD). We used nationwide Danish registers to investigate this hypothesis. Methods: We identified 4484 patients with a first time PD diagnosis between 2001 and 2008 from the Danish National Patient Register (DNPR) and 22416 population controls from the Danish Civil Registration System (CRS). Information on drug use was obtained from the National Prescription Registry (NPR). We used logistic regression to compute odds ratios (OR) for the association between treatment for HP and risk of PD. Results: Prescriptions for HP-eradication drugs and proton pump inhibitors (PPI) 5 or more years prior to the diagnosis of PD were associated with a 45% and 23% increase in PD risk, respectively. Hospitalizations and outpatient visits for gastritis and peptic/duodenal ulcers, however, were not associated with PD. Conclusions: Our population-based study suggests that chronic HP infections and/or gastritis contribute to PD or that these are PD-related pathologies that precede motor symptoms.
机译：背景与目的：据推测，幽门螺杆菌（HP）的胃肠道感染可导致帕金森氏病（PD）的发展。我们使用了全国范围内的丹麦登记册来研究这一假设。方法：我们从2001年至2008年间，从丹麦国家患者登记簿（DNPR）中识别了4484例首次PD诊断，并从丹麦民事登记系统（CRS）中识别了22416例人群。有关药物使用的信息可从国家处方注册中心（NPR）获得。我们使用逻辑回归计算HP治疗与PD风险之间的关联的比值比（OR）。结果：在诊断出PD之前5年或更长时间使用HP根除药物和质子泵抑制剂（PPI）的处方分别使PD风险增加45％和23％。然而，胃炎和消化性/十二指肠溃疡的住院治疗和门诊就诊与PD无关。结论：我们基于人群的研究表明，慢性HP感染和/或胃炎可导致PD，或者这些是运动症状之前与PD相关的病理。

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