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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Evolution of brain gray matter loss in Huntington's disease: A meta-analysis
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Evolution of brain gray matter loss in Huntington's disease: A meta-analysis

机译：亨廷顿舞蹈病脑灰质损失的演变：一项荟萃分析

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Background: Huntington's disease is characterized by neuronal loss throughout the disease course. Voxel-based morphometry studies have reported reductions in gray matter concentration (GMC) in many brain regions in patients with Huntington. The description of the time course of gray matter loss may help to identify some evolution markers. Here, we conducted a meta-analysis of voxel-based morphometry studies of Huntington's disease to describe the evolution of brain gray matter loss. Methods: A systematic search led to the inclusion of 11 articles on Huntington's disease (297 patients and 205 controls). We extracted data from patients with preclinical Huntington, patients with clinical Huntington, and controls. Finally, anatomical likelihood estimation analyses were conducted to identify GMC changes between preclinical patients and controls, between clinical patients and controls, and between preclinical and clinical patients. Results: Preclinical patients exhibited gray matter loss in the left basal ganglia and the prefrontal cortex. Clinical patients had bilateral gray matter loss in the basal ganglia, the prefrontal cortex, and the insula. The left striatum was smaller in clinical patients than in preclinical patients. Conclusions: Neurodegenerative processes associated with Huntington's disease, as assessed by GMC reduction, begin in the left hemisphere and extend to the contralateral hemisphere throughout the inexorable course of the disease. Changes in gray matter, especially the volumetric side ratio of the striatum, could represent a relevant biomarker for characterizing the different progression stages of the disease.
机译：背景：亨廷顿舞蹈病的特征是整个疾病过程中神经元的丢失。基于体素的形态学研究报告称，亨廷顿病患者许多大脑区域的灰质浓度（GMC）降低。灰质流失时间过程的描述可能有助于识别一些进化标记。在这里，我们对基于亨廷顿氏病的基于体素的形态学研究进行了荟萃分析，以描述脑灰质损失的演变。方法：系统搜索导致纳入11篇有关亨廷顿氏病的文章（297例患者和205例对照）。我们从临床前亨廷顿病患者，临床亨廷顿病患者和对照组中提取数据。最后，进行了解剖学可能性评估分析，以识别临床前患者与对照之间，临床患者与对照之间以及临床前与临床患者之间的GMC变化。结果：临床前患者的左基底神经节和前额叶皮层显示灰质减少。临床患者在基底神经节，前额叶皮层和岛突中双侧灰质丢失。临床患者的左纹状体比临床前患者小。结论：通过GMC减少评估，与亨廷顿氏病相关的神经退行性过程始于左半球，并在整个疾病的不可侵犯过程中延伸至对侧半球。灰质的变化，尤其是纹状体的容积侧比变化，可能代表了表征疾病不同进展阶段的相关生物标志物。

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