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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Physical therapy in Huntington's disease - toward objective assessments?
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Physical therapy in Huntington's disease - toward objective assessments?

机译：亨廷顿舞蹈病的物理疗法-是否可以进行客观评估？

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Background and purpose: Physical therapy is recommended for the treatment of Huntington's disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy interventions aimed at improving gait and posture. Methods: Twelve patients with Huntington disease received a predefined twice-weekly intervention focusing on posture and gait over 6 weeks. The GAITRite mat and a force plate were used for objective and quantitative assessments. The Unified Huntingtons Disease Rating Scale Total Motor Score, the timed Up &Go test, and the Berg Balance Scale were used as clinical outcome measures. Results: Significant improvements were seen in GAITRite measures after therapy. Improvements were also seen in the Up & Go test and Berg Balance Scale, whereas force plate measures and Total Motor Scores did not change. Conclusions: The results suggest that physical therapy has a positive effect on gait in Huntington's disease. The study shows that objective and quantitative measures of gait and posture may serve as endpoints in trials assessing the efficacy of physical therapy. They should be explored further in larger trials applying a randomized controlled setting.
机译：背景与目的：建议使用物理疗法治疗亨廷顿氏病，但几乎没有关于其功效的可靠研究。这可能部分是由于缺乏适当的结果指标。因此，我们调查了运动功能障碍的新型定量和客观评估在旨在改善步态和姿势的物理治疗干预措施的评估中的适用性。方法：十二名亨廷顿病患者接受了预先定义的每周两次干预，重点是姿势和步态，持续6周。 GAITRite垫和测力板用于客观和定量评估。统一的Huntingtons疾病评估量表总运动评分，定时的Up＆Go测验和Berg平衡量表用作临床结局指标。结果：治疗后，GAITRite措施明显改善。 Up＆Go测试和Berg平衡量表也显示出改进，而测力板测量和总运动得分未改变。结论：结果表明物理疗法对亨廷顿舞蹈病的步态有积极作用。研究表明，步态和姿势的客观和定量测量可以作为评估物理疗法疗效的试验的终点。在较大的试验中，应采用随机对照条件对它们进行进一步探讨。

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