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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >I123-FP-CIT single-photon emission tomography in patients with long-standing mixed tremor
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I123-FP-CIT single-photon emission tomography in patients with long-standing mixed tremor

机译：I123-FP-CIT单光子发射断层扫描在长期混合性震颤患者中的应用

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Background and purpose: Essential tremor is an abnormal movement characterized by postural and/or kinetic tremor. In some essential tremor patients, rest tremor (RT) is observed but it is not clear if this RT is a feature of essential tremor or a symptom of Parkinson's disease (PD). I123-FP-CIT single-photon emission tomography is used to distinguish essential tremor and PD. Objectives: To analyse I123-FP-CIT single-photon emission tomography in a larger series of patients with mixed tremor (i.e. action tremor associated with RT) without PD criteria. Methods: We studied 33 consecutives patients (18 men and 15 women) with mixed tremor, clinically and by neuroimaging in all cases. Results: I123-FP-CIT single-photon emission tomography was abnormal in 25 of our patients (75.7%) with mixed tremor, and we noted a reduced uptake mostly in the putamen. In our patients with abnormal imaging, RT was unilateral in 52%. In 15 of these 25 patients, putaminal reduced uptake was bilateral and symmetrical. In the other 10 patients, putaminal reduced uptake was asymmetrical or unilateral. In these 10 cases, six had a unilateral RT corresponding to (crossed) predominant reduced uptake in three cases. In our patients with normal imaging, RT was unilateral in 87.5%. Conclusions: This study shows that mixed tremor is a heterogeneous entity. The majority of patients with mixed tremor showed nigrostriatal dysfunction on I123-FP-CIT single-photon emission tomography, suggesting that mixed tremor may be a parkinsonian syndrome rather than a clinical variant of essential tremor.
机译：背景与目的：原发性震颤是一种以姿势性和/或运动性震颤为特征的异常运动。在一些原发性震颤患者中，观察到静息性震颤（RT），但尚不清楚该RT是否是原发性震颤的特征或帕金森氏病（PD）的症状。 I123-FP-CIT单光子发射断层扫描用于区分本质震颤和局部放电。目的：分析在没有PD标准的混合性震颤（即与RT相关的动作性震颤）的更大系列患者中的I123-FP-CIT单光子发射断层扫描。方法：我们对33例连续性混合震颤患者进行了研究，包括临床和神经影像学检查。结果：I123-FP-CIT单光子发射断层扫描在我们的25例混合性震颤患者中异常（75.7％），并且我们注意到大部分摄取在核壳中。在我们成像异常的患者中，RT单侧占52％。在这25例患者中的15例中，双侧对称对称地降低了肠吸收。在其他10例患者中，肠上皮吸收减少是不对称的或单侧的。在这10例病例中，有6例具有单侧RT，对应于3例中（交叉）显着减少的摄取。在我们的影像学正常的患者中，RT是单侧的，占87.5％。结论：这项研究表明混合性震颤是一个异质性实体。大多数混合性震颤患者在I123-FP-CIT单光子发射断层显像上显示出黑纹状体功能障碍，表明混合性震颤可能是帕金森综合征，而不是原发性震颤的临床变异。

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