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首页> 外文期刊>European Journal of Nuclear Medicine and Molecular Imaging >Diagnostic cutoff points for (1)(2)(3)I-MIBG myocardial scintigraphy in a Caucasian population with Parkinson's disease.
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Diagnostic cutoff points for (1)(2)(3)I-MIBG myocardial scintigraphy in a Caucasian population with Parkinson's disease.

机译：高加索帕金森氏病人群的（1）（2）（3）I-MIBG心肌闪烁显像的诊断临界点。

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PURPOSE: Molecular imaging with (123)I-metaiodobenzylguanidine (MIBG) has been used in Parkinson's disease (PD), but there is no consensual index to discriminate between normal and PD patients in the Caucasian population. The purpose of this study was to determine diagnostic cutoff points in the quantification of MIBG cardiac uptake in our population of PD patients. We have also calculated the reproducibility over a range of interpretation expertise. METHODS: The study included 14 PD patients and 14 normal age- and sex-matched controls. Heart to mediastinum ratios (H/M) were calculated at 15 min (H/M15m) and 4 h (H/M4h) post-injection by three observers with different interpretation expertise, one of whom drew the regions of interest at three different times. The intraobserver and interobserver reliability was calculated (interclass correlation coefficient and coefficient of variability). Diagnosis was estimated by maximizing the Youden index for H/M and washout ratios. Discrimination ability was assessed by the area under the curve (AUC). Sensitivity and specificity were reported, using our thresholds. RESULTS: The parameter with the best diagnostic accuracy was the H/M4h ratio, with a major AUC (0.976 area under the receiver-operating characteristic curve). The threshold was 1.43 with a 95% confidence interval of 1.37-1.50. Using this threshold, the sensitivity and specificity were 93 and 100%. The interobserver and intraobserver variabilities measuring this ratio were 3.2 and 3.1%, respectively. CONCLUSION: The diagnostic cutoff point for (123)I-MIBG myocardial scintigraphy in a Caucasian population with PD was 1.43 for the H/M4h index, with a good sensitivity and specificity. The technique is easy to use, with a good reproducibility over a range of interpretation expertise.
机译：目的：帕金森氏病（PD）中已使用（123）I-甲硫基苄基胍（MIBG）进行分子成像，但尚无共识性指标来区分白种人和正常人。本研究的目的是确定量化的PD患者人群MIBG心脏摄取的诊断临界点。我们还计算了多种解释技术的可重复性。方法：该研究包括14名PD患者和14名年龄和性别匹配的正常对照。由三个具有不同解释专业知识的观察员在注射后15分钟（H / M15m）和4小时（H / M4h）时计算心脏与纵隔之比（H / M）。其中一位观察员在三个不同的时间绘制了感兴趣的区域。计算观察者内和观察者间的可靠性（类间相关系数和变异系数）。通过最大化H / M和洗脱比率的尤登指数来估计诊断。通过曲线下面积（AUC）评估区分能力。使用我们的阈值报告了敏感性和特异性。结果：诊断准确度最高的参数是H / M4h比，其AUC较大（在接收器工作特性曲线下为0.976面积）。阈值为1.43，95％置信区间为1.37-1.50。使用此阈值，敏感性和特异性分别为93和100％。观察者之间和观察者内部差异测量该比率分别为3.2％和3.1％。结论：白人/ PD人群的（123）I-MIBG心肌闪烁显像的诊断截止点为H / M4h指数为1.43，具有良好的敏感性和特异性。该技术易于使用，在一系列解释专业知识上具有良好的可重复性。

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