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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Neuro-Behcet's disease in Caucasians: a study of 22 patients.
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Neuro-Behcet's disease in Caucasians: a study of 22 patients.

机译：高加索人的神经-贝塞特氏病：22位患者的研究。

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摘要

Several analyses of the neurological features of Behcet's disease (BD) have concluded that there are significant racial differences in its clinical expression. Other series, however, failed to elicit such differences. We aimed to describe in this retrospective survey the frequency, nature and relationship to systemic disease of the neurological features in a cohort of BD patients of Caucasian origin. We searched hospital records from nine District General or Regional Centre hospitals in south-west Great Britain and identified 22 individuals of Caucasian ethnic origin with neuro-BD, with a mean of 10 years follow-up per patient - the largest 'western' case series with the longest period of follow-up reported. We found that presentation with neurological features was commoner in our patients (23%) than Middle Eastern series (3-10%). Seizures (27%) were likewise commoner (0-5%), as was optic neuritis (9% compared with 1-2%). Two patients developed movement disorders (chorea and parkinsonism), which have only been rarely reported. Of further clinical significance, we noted that non-neuropsychiatric features: oral ulceration, intraocular inflammation and skin lesions - were virtually always present or exacerbated during neurological complications. Ethnicity--or conceivably environment--may play a significant role in the manifestation of neurological BD.
机译：对Behcet病（BD）的神经系统特征的一些分析得出的结论是，其临床表达存在明显的种族差异。然而，其他系列未能引起这种差异。我们的目的是在这项回顾性调查中描述一组白种人的BD患者的频率，性质及其与系统疾病的神经系统特征的关系。我们从英国西南部的9家地区综合医院或地区中心医院的医院记录中进行了搜索，并确定了22名患有神经性BD的白种人种族个体，平均每位患者10年的随访时间-最大的“西方”病例系列随访时间最长。我们发现，在我们的患者中，具有神经功能的表现比中东系列（3-10％）更常见（23％）。癫痫发作（27％）同样常见（0-5％），视神经炎（9％对1-2％）。两名患者出现了运动障碍（舞蹈症和帕金森综合症），很少报道。具有进一步的临床意义，我们注意到非神经精神病学特征：口腔溃疡，眼内炎症和皮肤病变-在神经系统并发症中几乎总是存在或加剧。种族-或可能是环境-可能在神经性BD的表现中起重要作用。

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