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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: A community study
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Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: A community study

机译：社区研究发现，与健康相关的其他多发性硬化症患者的生活质量和抑郁症状

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Background and purpose: Uncertain prognosis and modest treatment efficacy make multiple sclerosis (MS) a particularly difficult disease to adjust to for both patients and their significant others (SOs). Few studies have assessed health-related quality of life (HRQOL) and depressive symptoms in SOs of people with MS in the community. We assessed, and identified predictors of, HRQOL and depression in SOs of adults with MS. Methods: POSMOS (postal survey of self-assessed health in MS adults and SOs) is a longitudinal survey on a random sample of 251 people with MS in the Milan area. In 2010, SOs and contemporaneous controls completed the SF-36 and Chicago Multiscale Depression Inventory (CMDI). Results: Overall, 142 SOs (mean age 53.1years; 50% women, 65% partners) and 120 controls (similar to SOs for sex and education, but older) participated. By multivariable modeling of the SO plus control population, SF-36 vitality was lower in SOs (proportional odds ratio 0.45; 95% confidence interval 0.28-0.70), women (0.41; 0.27-0.64), and older subjects (0.98; 0.97-0.99). SF-36 mental health was also lower in SOs (0.62; 0.40-0.96) and women (0.43; 0.28-0.67). Regarding MS characteristics associated with HRQOL and depression in SOs, severe disability [Expanded Disability Status Scale (EDSS>6.5)] had no effect, whilst depressive symptoms (pathologic CMDI) negatively influenced most SF-36 and all CMDI scores in SOs. Conclusions: SOs had significantly lower vitality and psychological well-being than controls, identifying a burden in being the companion of a person with MS. This burden was unrelated to physical compromise but associated with depressive symptoms in MS.
机译：背景与目的：不确定的预后和适度的治疗效果使多发性硬化症（MS）成为特别难以适应患者及其重要其他患者（SOs）的疾病。很少有研究评估社区MS患者的健康相关生活质量（HRQOL）和抑郁症状。我们评估并确定了成年人MS SOs中HRQOL和抑郁的预测因素。方法：POSMOS（对MS成人和SO进行自我评估的健康状况的邮政调查）是一项对米兰地区251名MS患者进行随机抽样的纵向调查。在2010年，SO和同期控制人员完成了SF-36和芝加哥多级抑郁量表（CMDI）。结果：总体上，参加了142个SO（平均年龄53.1岁;女​​性50％，伴侣65％）和120个对照（类似于性和教育的SO，但年龄更大）。通过SO加对照人群的多变量建模，SO（比例优势比0.45; 95％置信区间0.28-0.70），女性（0.41; 0.27-0.64）和老年受试者（0.98; 0.97- 0.99）。 SOs（0.62; 0.40-0.96）和女性（0.43; 0.28-0.67）的SF-36心理健康水平也较低。关于与SOs的HRQOL和抑郁相关的MS特征，严重残疾[扩展残疾状态量表（EDSS> 6.5）]无影响，而抑郁症状（病理CMDI）对SOs中的大多数SF-36和所有CMDI评分均产生负面影响。结论：SOs的活力和心理健康水平明显低于对照组，这确定了与MS患者同伴的负担。这种负担与身体的损害无关，但与MS的抑郁症状有关。

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