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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients
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Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients

机译：MDS-UPDRS域与帕金森氏病患者健康相关的生活质量之间的关系

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Background and purpose: The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease (PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life (HRQoL) evaluations in PD patients. Methods: An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5D and PD Questionnaire - eight items (PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5D and PDQ-8) were performed. Results: The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5D index and the MDS-UPDRS ranged from -0.46 (Part IV) to -0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, nM-EDL and fluctuations was the main determinant for both the EQ-5D and PDQ-8 indexes. Conclusions: The MDS-UPDRS component most tightly related with the HRQoL measures was a combination of motor and non-motor experiences of daily living.
机译：背景与目的：运动障碍学会赞助的帕金森氏病统一疾病分级量表（MDS-UPDRS）是评估帕金森氏病（PD）的综合工具。本研究旨在确定PD患者中MDS-UPDRS组件与健康相关生活质量（HRQoL）评估之间的关系。方法：对435名PD患者进行了一项国际多中心横断面研究，这些患者通过MDS-UPDRS，Hoehn和Yahr（HY），PD的临床印象严重度，EQ-5D和PD问卷进行评估-八项（PDQ- 8）。进行了Spearman等级相关系数，探索性因素分析和多个线性回归模型（因变量EQ-5D和PDQ-8）。结果：参与者的年龄为66.71±10.32岁（男性51.5％）。 PD持续时间为8.52±6.14，中位HY为2（范围1-5）。 EQ-5D指数与MDS-UPDRS之间的相关性介于-0.46（第四部分）至-0.72（第二部分）之间，而PDQ-8指数的相关性介于0.47（第三部分）至0.74（第二部分）之间。在以MDS-UPDRS域为自变量的多元回归模型中，EQ-5D指数和PDQ-8的主要决定因素是第二部分，其次是第一部分。对嵌入MDS-中的主要PD表现进行因子分组后， UPDRS第III部分和第IV部分包含在多个回归模型中，由M-EDL，nM-EDL和波动形成的因素是EQ-5D和PDQ-8指数的主要决定因素。结论：与HRQoL措施最紧密相关的MDS-UPDRS组件是日常生活中运动和非运动经历的结合。

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