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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease
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The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease

机译：白蛋白高负荷是帕金森氏病患者进行性轻度认知障碍的预测指标

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Background and purpose: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). Methods: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. Results: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. Conclusions: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.
机译：背景与目的：为了评估白质高信号（WMHs）是否可以作为认知状态进展的独立预测因子，作者分析了WMHs对非痴呆帕金森病（PD）患者认知功能障碍的纵向影响。方法：共纳入111名PD患者，包括轻度认知障碍受试者（MCI，n = 65）和认知正常受试者（CN，n = 46）。根据他们后来是否被诊断患有PD痴呆症，将这些人分为MCI转化者（n = 22）或MCI非转化者（n = 43）和CN转化者（n = 18）或CN非转化者（n = 28）。或至少24个月的随访中的PD-MCI。检查了WMH负担和胆碱能通路高强度量表（CHIPS）以及它们与认知表现的纵向变化之间的关系。结果：与PD-MCI非转换器相比，PD-MCI转换器具有更大的WMH量（14421.0与5180.4，P <0.001）和更高的CHIPS评分（22.6与11.2，P = 0.001）。 Logistic回归分析显示，PD-MCI患者的WMH量（比值1.616，P = 0.009）和CHIPS评分（比值1.084，P = 0.007）与PD痴呆的转化独立相关。但是，PD-CN转换器和PD-CN非转换器之间的WMH量和CHIPS分数没有差异。在PD-MCI患者中，WMH量和CHIPS评分均与总体认知，语义流畅性和Stroop测试评分的纵向下降密切相关。结论：本研究表明，WMH负担是从PD-MCI转变为PD痴呆的重要预测指标，并且与基于额叶的认知能力的持续下降有关。

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