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首页> 外文期刊>European journal of anaesthesiology >Prevention of postoperative nausea and vomiting after laparoscopic gynaecological surgery. Combined antiemetic treatment with tropisetron and metoclopramide vs. metoclopramide alone.
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Prevention of postoperative nausea and vomiting after laparoscopic gynaecological surgery. Combined antiemetic treatment with tropisetron and metoclopramide vs. metoclopramide alone.

机译：预防腹腔镜妇科手术后的恶心和呕吐。与托吡司酮和胃复安相比单独的胃复安联合止吐治疗。

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BACKGROUND AND OBJECTIVE: Female patients undergoing gynaecological procedures, especially laparoscopically, are at high risk of postoperative nausea and vomiting. No available antiemetic is entirely effective. This double-blinded randomized trial examines the efficacy and safety of tropisetron and metoclopramide in combination and compares the results with metoclopramide alone in laparoscopic gynaecological surgery. METHODS: One hundred and twenty female patients scheduled for minor gynaecological laparoscopy, aged 27-43 years, were randomly allocated to receive pretreatment with metoclopramide 10 mg intravenously (n=57) or tropisetron 5 mg with metoclopramide 5 mg (n=63). RESULTS: Fewer patients in the combined treatment group experienced postoperative nausea and vomiting (14% vs. 37%, P=0.008) or needed rescue antiemetic treatment (3% vs. 16%, P=0.038). No significant adverse events were observed. CONCLUSIONS: The combination of the antiemetics was superior, which is probably explained by the fact that the two drugs have different sites of action, thus preventing emesis by blocking different pathways.
机译：背景与目的：接受妇科手术，尤其是腹腔镜手术的女性患者，术后恶心和呕吐的风险较高。没有可用的止吐药是完全有效的。这项双盲随机试验检查了托吡司琼和胃复安联合使用的有效性和安全性，并将其与单独使用胃复安在腹腔镜妇科手术中的结果进行了比较。方法：随机分配了120例计划进行妇科小腹腔镜检查的女性患者，年龄27-43岁，分别接受静脉注射甲氧氯普胺10 mg（n = 57）或托普司琼5 mg甲氧氯普胺5 mg（n = 63）进行预处理。结果：合并治疗组中较少患者发生术后恶心和呕吐（14％vs. 37％，P = 0.008）或需要紧急止吐治疗（3％vs. 16％，P = 0.038）。没有观察到明显的不良事件。结论：止吐药的组合效果更好，这可能是由于两种药物具有不同的作用部位，从而通过阻断不同的途径来预防呕吐的事实所致。

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