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首页> 外文期刊>European journal of clinical microbiology and infectious diseases: Official publication of the European Society of Clinical Microbiology >Increasing rates and clinical consequences of nalidixic acid-resistant isolates causing enteric fever in returned travellers: an 18-year experience.
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Increasing rates and clinical consequences of nalidixic acid-resistant isolates causing enteric fever in returned travellers: an 18-year experience.

机译：耐萘啶酸的分离株的增加率和临床后果在返回的旅行者中引起肠热：18年的经验。

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The purpose of this study was to examine the rate and clinical consequences of nalidixic acid-resistant (NAR) isolates in travellers with enteric fever presenting to a hospital in a developed country. We retrospectively examined microbiologically confirmed cases of enteric fever in adult returned travellers over an 18-year period presenting to two tertiary referral hospitals in Melbourne, Australia. There were 59 cases of Salmonella typhi infection, 43 cases of S. paratyphi A infection and two cases of S. paratyphi B infection. Most patients reported recent travel to India (36%) or Indonesia (29%). NAR isolates were commonly encountered (41% of all isolates), particularly from India (75%), Pakistan (80%) and Bangladesh (60%). The number of NAR isolates increased progressively after 2003. Patients with NAR isolates had prolonged mean fever clearance time (5.6 vs. 3.3 days, P = 0.03) and prolonged hospital stay (7.9 vs. 5.7 days, P = 0.02) compared to non-resistant isolates. This represents the largest report of NAR enteric fever in returned travellers. NAR isolates predominate in cases of enteric fever from South Asia and result in prolonged fever clearance time and hospital stay. Empiric therapy with alternative antibiotics such as ceftriaxone or azithromycin should be considered in patients with suspected enteric fever from this region.
机译：这项研究的目的是检查出现在发达国家医院就诊的肠热旅行者中耐萘啶酸（NAR）分离株的发生率和临床后果。我们回顾了经过微生物学证实的成人回肠病患者的肠炎热病例，这些病例在澳大利亚墨尔本的两家三级转诊医院接受了18年的治疗。伤寒沙门氏菌感染59例，副伤寒沙门氏菌A感染43例，副伤寒沙门氏菌B感染2例。大多数患者报告最近去过印度（36％）或印度尼西亚（29％）。经常遇到NAR分离株（占所有分离株的41％），特别是印度（75％），巴基斯坦（80％）和孟加拉国（60％）。 2003年之后，NAR分离株的数量逐渐增加。与非NAR分离株相比，NAR分离株的患者平均发烧时间延长了（5.6 vs. 3.3天，P = 0.03），住院时间延长了（7.9 vs. 5.7天，P = 0.02）。抗性分离株。这是返回旅行者中NAR肠热的最大报告。在来自南亚的肠热病例中，NAR分离株占主导地位，并导致较长的热清除时间和住院时间。对于怀疑来自该地区的肠热的患者，应考虑使用替代性抗生素如头孢曲松或阿奇霉素的经验疗法。

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