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首页> 外文期刊>Bio-medical materials and engineering >Effect of gap junctions on the firing patterns and synchrony for different external inputs in the striatal fast-spiking neuron network
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Effect of gap junctions on the firing patterns and synchrony for different external inputs in the striatal fast-spiking neuron network

机译：间隙连接对纹状体快速突触神经元网络中不同外部输入的放电模式和同步性的影响

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摘要

Gap junctions are the mechanism for striatal fast-spiking interneurons (FSIs) to interconnect with each other and play an important role in determining the physiological functioning of the FSIs. To investigate the effect of gap junctions on the firing activities and synchronization of the network for different external inputs, a simple network with least connections and a Newman-Watts small-world network were constructed. Our research shows that both properties of neural networks are related to the conductance of the gap junctions, as well as the frequency and correlation of the external inputs. The effect of gap junctions on the synchronization of network is different for inputs with different frequencies and correlations. The addition of gap junctions can promote the network synchrony in some conditions but suppress it in others, and they can inhibit the firing activities in most cases. Both the firing rate and synchronization of the network increase along with the increase of the electrical coupling strength for inputs with low frequency and high correlation. Thus, the network of coupled FSIs can act as a detector for synchronous synaptic input from cortex and thalamus.
机译：间隙连接是纹状体快速加标中枢神经元（FSI）相互连接的机制，并且在确定FSI的生理功能中起重要作用。为了研究间隙连接对不同外部输入的点火活动和网络同步的影响，构建了连接最少的简单网络和纽曼-瓦茨小世界网络。我们的研究表明，神经网络的这两个属性都与间隙连接的电导以及外部输入的频率和相关性有关。间隙连接对网络同步的影响对于具有不同频率和相关性的输入是不同的。间隙连接的添加在某些情况下可以促进网络同步，而在其他情况下则可以抑制网络同步，并且在大多数情况下，它们可以抑制触发活动。对于低频和高相关性的输入，网络的触发速率和同步性都随着电耦合强度的增加而增加。因此，耦合的FSI的网络可以充当来自皮质和丘脑的同步突触输入的检测器。

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