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首页> 外文期刊>European journal of clinical nutrition >Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia.
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Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia.

机译:在两个相似的印度人口群体中,一个居住在印度,另一个居住在澳大利亚的悉尼,患冠心病的危险因素。

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OBJECTIVE:: To identify the prevalence of coronary risk factors among South Asian Indians in Australia and India. DESIGN:: Cross-sectional intercountry comparison. SUBJECTS:: Healthy volunteers aged 23-75 y recruited from the Indian community in Sydney Australia (n=125), and their nominated relatives in India, (n=125). RESULTS:: The two groups were of similar background with over 90% of the group in India being siblings, parents or relatives of the group in Australia. There was no difference in the populations between India and Australia with regard to mean age (40+/-11.5 vs 39+/-10.3 y), body mass index (BMI) (25+/-3.3 vs 25+/-3.5 kg/m(2)), lipoprotein (a) (178 vs 202 mg/l), total cholesterol (5.3+/-1.3 vs 5.3+/-1.2 mmol/l) or triglyceride (1.7+/-0.8 vs 1.7+/-0.8 mmol/l). The group in India had higher insulin (median values) (139 vs 83 pmol/l, P=0.0001), waist-to-hip ratio (WHR) (0.88+/-0.08 vs 0.85+/-0.09, P=0.01), exercise time (23.7+/-32.7 vs 17.2+/-23.2 h/week, P=0.07), lower waist (83+/-10.0 vs 85+/-11.1 cm, P=0.05) and high-density lipoprotein (0.9+/-0.3 vs 1.1+/-0.6 mmol/l, P=0.02). Women in India had lower BMI (22.7+/-2.9 vs 25.3+/-4.2 kg/m(2), P<0.001), higher insulin (182 vs 90 pmol/l, P<0.001), WHR (0.86+/-0.08 vs 0.77+/-0.06, P<0.001)) and prevalence of abdominal obesity (% WHR >0.8, 73 vs 23%, P<0.001; odds of waist >90 cm=2.3, P<0.05). Men in India had the same BMI, lower waist (85.5+/-8.8 vs 92.9+/-7.2 cm, P<0.001) and WHR (0.89+/-0.09 vs 0.93+/-0.05, P<0.01) but higher insulin (137 vs 76 pmol/l). CONCLUSION:: The group in Australia (especially women) have a more favourable disease risk profile than those in India. The fact that the groups are of such similar background and partly related, make it unlikely that changes due to migration have a strong genetic bias. In contrast to other studies, the absence here of excessive weight gain on migration may be a key factor in disease risk prevention.European Journal of Clinical Nutrition (2004) 58, 751-760. doi:10.1038/sj.ejcn.1601873
机译:目的:确定澳大利亚和印度的南亚印第安人中冠心病危险因素的患病率。设计::跨地区比较。受试者:从澳大利亚悉尼的印度社区(n = 125)招募的年龄在23-75岁之间的健康志愿者及其在印度的提名亲戚(n = 125)。结果:两组的背景相似,印度组中90%以上是澳大利亚的同胞,父母或亲戚。在印度和澳大利亚之间,平均年龄(40 +/- 11.5岁对39 +/- 10.3岁),体重指数(BMI)(25 +/- 3.3对25 +/- 3.5公斤)没有差异/ m(2)),脂蛋白(a)(178 vs 202 mg / l),总胆固醇(5.3 +/- 1.3 vs 5.3 +/- 1.2 mmol / l)或甘油三酸酯(1.7 +/- 0.8 vs 1.7 + / -0.8mmol / l)。印度的组的胰岛素水平较高(中值)(139 vs 83 pmol / l,P = 0.0001),腰臀比(WHR)(0.88 +/- 0.08 vs 0.85 +/- 0.09,P = 0.01) ,运动时间(23.7 +/- 32.7 vs 17.2 +/- 23.2 h / week,P = 0.07),下腰围(83 +/- 10.0 vs 85 +/- 11.1 cm,P = 0.05)和高密度脂蛋白( 0.9 +/- 0.3对1.1 +/- 0.6 mmol / l,P = 0.02)。印度女性的BMI较低(22.7 +/- 2.9 vs 25.3 +/- 4.2 kg / m(2,P <0.001),胰岛素较高(182 vs 90 pmol / l,P <0.001),WHR(0.86 + / -0.08 vs.0.77 +/- 0.06,P <0.001))和腹部肥胖的患病率(%WHR> 0.8,73 vs 23%,P <0.001;腰部赔率> 90 cm = 2.3,P <0.05)。印度男性具有相同的BMI,下腰(85.5 +/- 8.8 vs 92.9 +/- 7.2 cm,P <0.001)和WHR(0.89 +/- 0.09 vs 0.93 +/- 0.05,P <0.01)但胰岛素更高(137对76 pmol / l)。结论:澳大利亚的人群(尤其是女性)比印度的人群具有更有利的疾病风险。这些群体具有相似的背景并且部分相关,这一事实使得因迁徙而引起的变化不太可能具有强烈的遗传偏见。与其他研究相反,这里没有过度增加体重增加可能是预防疾病风险的关键因素。欧洲临床营养杂志(2004)58,751-760。 doi:10.1038 / sj.ejcn.1601873

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